国际口腔医学杂志2017，Vol.44Issue(1)：103-107,5.DOI:10.7518/gjkq.2017.01.021
白假丝酵母菌与龋病的相关性及其致龋机制
Saccharomyces albicans:its dental caries correlation and mechanism
摘要
Abstract
Saccharomyces albicans(S. albicans) is a Gram-positive fungus and widely exists in the upper respiratory tract, intestinal canal, and vagina of healthy people. S. albicans does not cause diseases in a state of symbiosis with the host. The ability of S. albicans to switch its morphotype from yeast to hyphal forms contributes to its pathogenesis and leads to oral mucosa infection and dental caries. In oral biofilms of caries-affected people, an interaction may exist between S. albicans and Streptococcus mutans(S. mutans) leading to the development of dental caries. S. albicans tends to adhere tightly to Streptococcus gordonii(S. gordonii), that is, a polysaccharide existing on the surface of the cell wall of S. gordonii is one of the adhesion receptors of S. albicans. S. gordonii can alleviate the inhibition effect of quorum-sensing mechanism on hyphae formation and biofilm development of S. albicans, thereby increasing the biomass. This review focused on S. albicans, the correlation of S. albicans and dental caries, and the research progress on the possible specific mechanism involved in the occurrence and development of dental caries caused by the interactions of S. albicans, together with S. mutans, S. gordonii, and other oral bacteria. This study aims to provide ideas and references for future clinical research.关键词
白假丝酵母菌/龋病/变异链球菌/格氏链球菌Key words
Saccharomyces albicans/dental ceries/Streptococcus mutans/Streptococcus gordonii分类
医药卫生引用本文复制引用
刘诗雨,何金枝,李明云..白假丝酵母菌与龋病的相关性及其致龋机制[J].国际口腔医学杂志,2017,44(1):103-107,5.基金项目
国家自然科学基金（81400501）；口腔疾病研究国家重点实验室专项经费（SKLOD201525）；四川大学大学生创新训练计划 （）
