国际口腔医学杂志2017，Vol.44Issue(1)：108-113,6.DOI:10.7518/gjkq.2017.01.022
微小RNA在骨分化过程中的作用机制
Role and mechanism of microRNA in osteogenic differentiation
摘要
Abstract
The problem of insufficient bone usually occurs during oral implantology treatment. The use of bone substitute materials is one of the most important methods to reconstruct bone defects clinically. Therefore, the properties and molecular mechanisms of these bone substitute materials have been a controversial topic in research. MicroRNA(miRNA) is a short, non-coding RNA. It regulates cell differentiation, proliferation, apoptosis, and other pathophysiological processes by post-transcription. In addition, miRNA can regulate the dynamic remodeling of bone tissue by affecting the expression of osteogenic factors and the activation of osteogenic signal transduction pathway. This paper reviews the role of miRNA in osterix, core binding factorα1, Smad, and transforming growth factor-β. The regulating function of miRNA in the signal transduction pathways of bone morphogenetic protein, wingless-type mice mammary tumor virus integration site family, mitogen-activated protein kinase, and adipogenesis is investigated. The relation of miRNA with dental materials and its application in repairing bone defects are also reviewed.关键词
微小RNA/骨分化/骨分化调节因子/信号转导通路Key words
microRNA/osteogenic differentiation/regulatory factor of osteogenic differentiation/signal transduction pathway分类
生物科学引用本文复制引用
刘润恒,刘于冬,陈卓凡..微小RNA在骨分化过程中的作用机制[J].国际口腔医学杂志,2017,44(1):108-113,6.基金项目
国家自然科学基金 （）
