广西医学2017，Vol.39Issue(1)：12-14,3.DOI:10.11675/j.issn.0253-4304.2017.01.04
急诊经皮冠状动脉介入治疗对急性心肌梗死患者N末端B型利钠肽原及左心室重构的影响
Effect of emergency percutaneous coronary intervention on N-terminal pro-B-type natriuretic peptide and left ventricle remodeling in patients with acute myocardial infarction
摘要
Abstract
Objective To investigate the effect of emergency percutaneous coronary intervention ( PCI) on N-terminal pro-B-type natriuretic peptide(NT-proBNP) and left ventricular remodeling in patients with acute myocardial infarction (AMI).Methods Sixty-nine patients with AMI were randomly divided into observation group (n=36) or control group(n=33).The observation group was treated with PCI,while the control group was treated with routine drug therapy .Plasma NT-proBNP level, left ventricular end systolic diameter (LVESD),left ventricular end diastolic diameter(LVEDD),and left ventricular ejection fraction(LVEF) were measured in both groups 24 hours before treatment,24 and 48 hours after treatment.Results After treatment,plasma NT-proBNP level in the observation group was significantly lower than that in the control group (P<0.05),and it tended to decrease with the time of therapy in both groups (P<0.05). There were no statistical differences in LVESD ,LVEDD,or LVEF between the two groups (P>0.05),but both LVESD and LVEDD in the two groups decreased with the increase of the time of therapy (P<0.05),while LVEF in the two groups increased with the increase of the time of therapy(P<0.05).Conclusion Emergency PCI can significantly reduce the content of NT-proBNP,and improve the left ventricular function in patients with AMI .关键词
急性心肌梗死/经皮冠状动脉介入/N末端B型利钠肽原/心室重构Key words
Acute myocardial infarction/Percutaneous coronary intervention/N-terminal pro brain natriuretic peptide/Ventricle remodeling分类
医药卫生引用本文复制引用
黄明剑,温志浩,潘朝锌,何新兵..急诊经皮冠状动脉介入治疗对急性心肌梗死患者N末端B型利钠肽原及左心室重构的影响[J].广西医学,2017,39(1):12-14,3.基金项目
国家自然科学基金（81403381）；广西自然科学基金 （）
