海南医学院学报2017，Vol.23Issue(2)：201-204,208,5.DOI:10.13210/j.cnki.jhmu.20161115.037
左心衰竭患者血清 MR-ProANP、NT-ProBNP 含量与泵血功能、心室重构的相关性研究
Correlation of serum MR-ProANP and NT-ProBNP content with pump function and ventricular remodel ing in patients with left heart failure
摘要
Abstract
[ABSTRACT]Objective:To study the correlation of serum MR-ProANP and NT-ProBNP content with pump function and ventricular remodeling in patients with left heart failure.Methods:A total of 104 patients with chronic heart failure treated in our hospital between May 2013 and May 201 6 were selected as the heart failure group of the research and 95 healthy volunteers receiving physical examination in our hospital over the same period were selected as the control group of the research.Serum was collected to detect the content of MR-ProANP,NT-ProBNP as well as ventricular remodeling-related molecules,and car-diac color Doppler ultrasonography was conducted to determine the heart pump function- and myocardial remodeling-related pa-rameters.Results:Serum MR-ProANP,NT-ProBNP,MMP2,MMP9,MMP10,PICP and PⅢNP content as well as ultra-sound parameters IVSd,PWT,LVMI,MWS levels of heart failure group were significantly higher than those of control group;ultrasound parameters LAEF,LAPEF and LAAEF levels were significantly lower than those of control group;serum MR-ProANP and NT-ProBNP content were positively correlated with ultrasound parameters IVSd,PWT,LVMI,MWS as well as serum MMP2,MMP9,MMP10,PICP and PⅢNP content,negatively correlated with ultrasound parameters LAEF, LAPEF and LAAEF,and the correlation coefficients of MR-ProANP with these indexes were all higher than those of NT-ProBNP.Conclusions:Serum MR-ProANP and NT-ProBNP content in patients with left heart failure are closely related to the pump function and ventricular remodeling,and MR-ProANP is more valuable for evaluating pump function decrease and ven-tricular remodeling increase.关键词
慢性心力衰竭/MR-ProANP/NT-ProBNP/泵血功能/心室重构Key words
Chronic heart failure/MR-ProANP/NT-ProBNP/Ventricular remodeling分类
医药卫生引用本文复制引用
何巧,黄勇..左心衰竭患者血清 MR-ProANP、NT-ProBNP 含量与泵血功能、心室重构的相关性研究[J].海南医学院学报,2017,23(2):201-204,208,5.基金项目
重庆市医学科研基金(2011A021013)@@@@It is supported by Medical Scientific Research Foundation of Chongqing 2011A021013 （2011A021013）
