海南医学院学报2017，Vol.23Issue(2)：232-235,4.DOI:10.13210/j.cnki.jhmu.20161230.001
硼替佐米联合地塞米松治疗老年多发性骨髓瘤的疗效及对免疫抑制因子、免疫细胞水平的影响
Effects of bortezomib and dexamethasone combination on treating senile multiple myeloma and influence on immune suppressed factors and immune cell levels
摘要
Abstract
[ABSTRACT]Objective:To investigate the effects of bortezomib and dexamethasone combination on treating senile multi-ple myeloma and influence on immune suppressed factors and immune cell levels.Methods:A total of 80 cases of patients with multiple myeloma treated in our hospital from October 2013 to July 201 5 were selected as investigate subjects.They were ran-domly divided into observation group with 43 cases and control group with 37 cases.For observation group,treatment of borte-zomib and dexamethasone combination was provided.For control group,vincristine + epirubicin + dexamethasone treatment was provided.After three courses,effects on two groups of patients were compared,and immune suppressed factors and im-mune cell levels before and after treatment in different periods were compared.Results:After three courses of treatment,the total effective rate in observation group was significantly higher than control group (χ2 =14.687,P <0.01).Before treatment, IL-6,IL-1 7,TGF-β,CD3 + CD4 + ,CD3 + CD8 + and CD3 + CD4 +/CD3 + CD8 + between the two group of patients were com-pared and no significant difference showed (P >0.05 );After treatment for 6 weeks,IL-6,IL-1 7 levels in observation group were significantly decreased compared with the same group before treatment (P < 0.05,P < 0.01 );After treatment for 12 weeks,IL-6,IL-1 7 and TGF-βlevels in observation group were significantly decreased compared with the same group before treatment (P <0.05,P <0.01);After treatment,IL-6,IL-1 7 levels in observation group were significantly lower than control group at the same phase (P <0.05,P <0.01).After treatment for 12 weeks,CD3 + CD4 + ,CD3 + CD4 +/CD3 + CD8 + in obser-vation group were significantly higher than the same group before treatment (P <0.05),and significantly higher than control group at the same phase (P < 0.05 );CD3 + CD8 + in observation group was significantly lower than the same group before treatment (P <0.01),and significantly lower than control group at the same phase (P <0.05 ).Conclusions:Compared with vincristine+epirubicin+dexamethasone treatment,bortezomib and dexamethasone combination on treating senile multiple my-eloma had more significant effects,which deserves further clinical researches.关键词
多发性骨髓瘤/硼替佐米/地塞米松/免疫抑制因子/免疫细胞/老年人Key words
Multiple myeloma/Bortezomib/Dexamethasone/Immune suppressed factors/Immune cell分类
医药卫生引用本文复制引用
王欢,赵真,张滔,马清,血液,熊梅..硼替佐米联合地塞米松治疗老年多发性骨髓瘤的疗效及对免疫抑制因子、免疫细胞水平的影响[J].海南医学院学报,2017,23(2):232-235,4.基金项目
北京市自然科学基金(9231894) （9231894）
