海南医学院学报2017，Vol.23Issue(2)：270-272,276,4.DOI:10.13210/j.cnki.jhmu.20161115.008
非小细胞肺癌 CT 灌注参数与血管新生、细胞增殖以及肿瘤负荷的相关性研究
Correlation study between CT perfusion parameters of non-small cell lung cancer and angio-genesis,cell prol iferation as well as tumor load
摘要
Abstract
[ABSTRACT]Objective:To study the correlation between CT perfusion parameters of non-small cell lung cancer and an-giogenesis,cell proliferation as well as tumor load.Methods:Patients diagnosed with non-small cell lung cancer in our hospital between May 2012 and December 201 5 were selected,CT perfusion was used to measure the blood volume (BV),blood flow (BF)and time to peak (TTP)of lung cancer lesions and unaffected-side lung tissue,and the lung cancer tissue and para-carci-noma tissue were collected to determine the expression of angiogenesis and cell proliferation molecules.Results:BV and BF of non-small cell lung cancer tissue were significantly higher than those of unaffected-side lung tissue while TTP was significantly shorter than that of unaffected-side lung tissue;PCDGF,bFGF,FGFR,VEGF,VEGFR,TCF3,Skp2,Livin and Survivin expression in non-small cell lung cancer tissue were significantly higher than those in para-carcinoma tissue,positively correla-ted with BV and BF,and negatively correlated with TTP.Conclusions:CT perfusion parameters BV,BF and TTP are closely related to the expression of angiogenesis molecules and cell proliferation molecules in non-small cell lung cancer lesions,and are valuable for the assessment of angiogenesis and cell proliferation.关键词
非小细胞肺癌/CT 灌注成像/血管新生/细胞增殖Key words
Non-small cell lung cancer/CT perfusion/Angiogenesis/Proliferation分类
医药卫生引用本文复制引用
林发洪..非小细胞肺癌 CT 灌注参数与血管新生、细胞增殖以及肿瘤负荷的相关性研究[J].海南医学院学报,2017,23(2):270-272,276,4.基金项目
四川省卫生厅科研项目(130458)@@@@It is supported by Scientific Research Project of Sichuan Provincial Health Department 130458 （130458）
