海南医学院学报2017，Vol.23Issue(2)：277-280,4.DOI:10.13210/j.cnki.jhmu.20161115.009
2型糖尿病合并骨质疏松患者 DEXA 骨密度测量结果与血清细胞因子、胰岛素抵抗的关系
Relationship between DEXA bone mineral density measurement results and serum cytokines as well as insul in resistance in patients with type 2 diabetes mell itus and osteoporosis
摘要
Abstract
[ABSTRACT]Objective:To study the relationship between DEXA bone mineral density measurement results and serum cytokines as well as insulin resistance in patients with type 2 diabetes mellitus and osteoporosis.Methods:Patients newly diag-nosed with type 2 diabetes were selected and divided into normal bone mass group,osteopenia group and osteoporosis group ac-cording to the DEXA femoral neck bone mineral density measurement results,the bone mineral density of all parts in of three groups of patients were measured,and serum was collected to determine the levels of bone metabolism indexes,cytokines and insulin.Results:Femoral trochanter,Ward's area as well as the 2-4th lumbar vertebra bone mineral density values of osteopenia group and osteoporosis group were significantly lower than those of normal bone mass group,and the femoral trochanter, Ward's area as well as the 2-4th lumbar vertebra bone mineral density values of osteoporosis group were significantly lower than those of osteopenia group;serum N-MID,PINP and BGP levels of osteopenia group and osteoporosis group were significantly lower than those of normal bone mass group whileβ-CTX,TRACP5b,Ins,Chemerin,TNF-α,IL-1βand MCP-1 levels were significantly higher than those of normal bone mass group;serum N-MID,PINP and BGP levels of osteoporosis group were significantly lower than those of osteopenia group whileβ-CTX,TRACP5b,Ins,Chemerin,TNF-α,IL-1βand MCP-1 levels were significantly higher than those of osteopenia group;serum Ins,Chemerin,TNF-α,IL-1β and MCP-1 levels were nega-tively correlated with N-MID,PIN and BGP levels,and positively correlated with serumβ-CTX and TRACP5b levels.Conclu-sions:Excessively synthesized inflammatory factors and compensatory hyperinsulinemia in patients with type 2 diabetes melli-tus and osteoporosis can promote bone resorption and inhibit bone formation,thus resulting in the osteopenia in multiple areas of the body.关键词
2 型糖尿病/骨质疏松/骨密度/炎症因子/胰岛素抵抗Key words
Type 2 diabetes mellitus/Osteoporosis/Inflammatory factors/Insulin resistance分类
医药卫生引用本文复制引用
王兵,杨勋能..2型糖尿病合并骨质疏松患者 DEXA 骨密度测量结果与血清细胞因子、胰岛素抵抗的关系[J].海南医学院学报,2017,23(2):277-280,4.基金项目
四川省卫生厅科研项目(140263) （140263）
