海南医学院学报2017，Vol.23Issue(3)：289-291,295,4.DOI:10.13210/j.cnki.jhmu.20161207.001
虫草素调节肺癌细胞株 A549恶性生物学行为的实验研究
Cordycepin regulates the mal ignant biological behaviors of lung cancer cell l ines A549
摘要
Abstract
[ABSTRACT]Objective:To study the effect of cordycepin on proliferation,apoptosis and invasion-related molecule expres-sion in lung cancer cell lines A549.Methods:Lung cancer cell lines A549 were cultured and treated with different doses of cordycepin (0,0.25,0.5,1.0,2.0 and 4.0 ng/mL)for 24 h,and then the proliferation,apoptosis and invasion-related mole-cule mRNA expression in cells were detected.Results:After 0.25,0.5,1.0,2.0 and 4.0 ng/mL cordycepin treatment, Caspase-3,Caspase-8,NOX1 and LATS1 mRNA expression were significantly higher than those after 0 ng/mL cordycepin treatment while CyclinD1,Bcl-2,c-Myc,c-FLIP,TRAF6,N-cadherin and Vimentin mRNA expression were significantly lower than those after 0 ng/mL cordycepin traetment;the greater the cordycepin dosage,the higher the Caspase-3,Caspase-8, NOX1 and LATS1 mRNA expression,and the lower the CyclinD1,Bcl-2,c-Myc,c-FLIP,TRAF6,N-cadherin and Vimentin mRNA expression.Conclusion:Cordycepin can promote pro-apoptosis gene expression and inhibit pro-proliferation and pro-in-vasion gene expression in lung cancer cell lines A549.关键词
肺癌/虫草素/增殖/凋亡/侵袭Key words
Lung cancer/Cordycepin/Proliferation/Apoptosis/Invasion分类
医药卫生引用本文复制引用
史宁,郭宏举,王欢,常李荣..虫草素调节肺癌细胞株 A549恶性生物学行为的实验研究[J].海南医学院学报,2017,23(3):289-291,295,4.基金项目
国家自然科学基金面上项目(3077263) （3077263）
