海南医学院学报2017，Vol.23Issue(3)：313-315,3.DOI:10.13210/j.cnki.jhmu.20160814.014
左室舒张功能衰竭患者 NF-κB 和 TGF-β1与心室重构的相关性分析
Correlation between ventricular remodel ing and left ventricular distotic dysfuction
摘要
Abstract
[ABSTRACT]Objective:To evaluate the left ventricular failure (DHF)expression changes in peripheral blood of patients with NF- κB,TGF- β1,its correlation with left ventricular remodeling and its clinical pathological significance.Methods;A total of 1 50 patients with diastolic heart failure (DHF)(experimental group)and 30 healthy persons (control group)were en-rolled and the peripheral blood samples were collected,the expression level of the double antibody sandwich ELISA method for detection of TGF-β1 and NF- κB were detected.Results:TGF-β1,NF- κB levels were higher in peripheral blood of patients of the experiment group than that of the control group(P <0.05).TGF-β1 and NF-κB levels increased with severity of heart fail-ure (P <0.05).Correlation analysis showed that TGF-β1,left ventricular mass index,NF-κB level and mean left ventricular wall stress is positively correlated(P <0.01),indicating there is a significant correlation between TGF-β1,NF-κB level and the severity of ventricular remodeling.Conclusion:TGF-β1,NF-κB expression levels have undergone significant changes as the DHF serum markers in the peripheral blood,which plays an important role in the development of ventricular remodeling.关键词
心室重构/核转录因子/转化生长因子β1/心力衰竭Key words
Ventricular remodeling/Nuclear transcription factor/Transforming growth factor beta 1/Heart failure分类
医药卫生引用本文复制引用
陈万,李佑美,首云锋..左室舒张功能衰竭患者 NF-κB 和 TGF-β1与心室重构的相关性分析[J].海南医学院学报,2017,23(3):313-315,3.基金项目
中国高校医学期刊临床专项资金项目(11221665) （11221665）
