海南医学院学报2017，Vol.23Issue(3)：355-358,4.DOI:10.13210/j.cnki.jhmu.20161122.003
糖尿病合并良性前列腺增生患者尿流动力学特征与胰岛素抵抗及血清损伤介质的相关性
Correlation of urodynamic characteristics with insul in resistance and serum damage media in diabetic patients with benign prostatic hyperplasia
摘要
Abstract
[ABSTRACT]Objective:To study the correlation of urodynamic characteristics with insulin resistance and serum damage media in patients with diabetes and benign prostatic hyperplasia (BPH).Methods:A total of 45 patients with type 2 diabetes mellitus and BPH treated in our hospital between May 2014 and August 201 6 were selected as DM+BPH group,58 patients with BPH alone were selected as BPH group,50 healthy volunteers were selected as control group,urodynamic tester was used to measure the maximum flow rate (MFR),postvoid residual (PVR)and detrusor pressure at maximum flow rate (Pdet),and serum was collected to determine insulin resistance indexes and oxidative stress indexes.Results:MFR and Pdet of DM+BPH group were significantly lower than those of control group while PVR was significantly higher than that of control group.MFR of BPH group was significantly lower than that of control group while PVR and Pdet were significantly higher than those of control group.MFR and Pdet of DM+BPH group were significantly lower than those of BPH group while PVR was signifi-cantly higher than that of BPH group.HOMA-β,ISI as well as serum MnSOD,CuZnSOD and GPx levels of DM+BPH group and BPH group were significantly lower than those of control group while HOMA-IR as well as serum Trx and TXNIP levels was significantly higher than those of control group.HOMA-β,ISI as well as serum MnSOD,CuZnSOD and GPx levels of DM+BPH group were significantly lower than those of BPH group,positively correlated with MFR and Pdet,and negatively cor-related with MFR,and HOMA-IR as well as serum Trx and TXNIP levels was significantly higher than those of BPH group, negatively correlated with MFR and Pdet,and positively correlated with MFR.Conclusion:Insulin resistance and oxidative stress injury are the mechanisms that cause the urodynamic changes in patients with diabetes and BPH.关键词
2 型糖尿病/良性前列腺增生/尿流动力学/胰岛素抵抗/氧化应激损伤Key words
Type 2 diabetes mellitus/Benign prostatic hyperplasia/Urodynamics/insulin resistance/Oxidative stress injury分类
医药卫生引用本文复制引用
姜仲坪,魏捷..糖尿病合并良性前列腺增生患者尿流动力学特征与胰岛素抵抗及血清损伤介质的相关性[J].海南医学院学报,2017,23(3):355-358,4.基金项目
2015湖北省卫计委科研项目(WJ2015MA019) （WJ2015MA019）
