海南医学院学报2017，Vol.23Issue(3)：383-386,4.DOI:10.13210/j.cnki.jhmu.20161122.001
椎间孔镜手术与传统开窗手术治疗腰椎间盘突出症的术后疼痛介质、炎性因子比较
Comparison of pain media and inflammatory factors after percutaneous transforaminal endo-scopic discectomy and traditional fenestration operation treatment of protrusion of lumbar in-tervertebral disc
摘要
Abstract
Objective:To compare the differences in pain mediators and inflammatory factors after percutaneous transforaminal endoscopic discectomy and traditional fenestration operation treatment of protrusion of lumbar intervertebral disc. Methods:A total of 80 patients with protrusion of lumbar intervertebral disc treated in our hospital were collected and divided into observation group and control group (n =40)according to randomized parallel contrast.Control group received traditional fenestration operation and observation group received percutaneous transforaminal endoscopic discectomy.Before operation and 1 week after operation,fluorescence spectrophotometry was used to determine serum pain medium levels;ELISA was used to determine pro-inflammatory factor and anti-inflammatory factor levels.Results:Before undergoing operation,differences in serum pain medium and inflammatory factor levels were not statistically significant between two groups (P >0.05).1 week after operation,serum pain media norepinephrine (NE),dopamine (DA),5-hydroxytryptamine (5-HT),prostaglandin E2 (PGE2) and substance P (SP)levels as well as pro-inflammatory factors interleukin-1β(IL-1β),interleukin-6 (IL-6),interleukin-18(IL-18)and tumor necrosis factor alpha (TNF-α)levels of observation group were lower than those of control group while serum anti-inflammatory factors interleukin-4 (IL-4),interleukin 10 (IL-10),soluble tumor necrosis factor receptorⅠ (sTNFRI) levels were higher than those of control group,and differences between groups were statistically significant (P <0.05). Conclusion:Percutaneous transforaminal endoscopic discectomy can effectively treat protrusion of lumbar intervertebral disc and is more advantageous in alleviating patients’perception of pain and reducing inflammation.关键词
腰椎间盘突出症/椎间孔镜手术/疼痛介质/炎性因子Key words
Protrusion of lumbar intervertebral disc/Percutaneous transforaminal endoscopic discectomy/Pain medi-um/Inflammatory factor分类
医药卫生引用本文复制引用
刘世伟,王翔奕..椎间孔镜手术与传统开窗手术治疗腰椎间盘突出症的术后疼痛介质、炎性因子比较[J].海南医学院学报,2017,23(3):383-386,4.基金项目
四川卫生厅科研课题(130914)@@@@This study was supported by Sichuan provincial Health Department grant No .130914 （130914）
