海南医学院学报2017，Vol.23Issue(3)：404-407,4.DOI:10.13210/j.cnki.jhmu.20161122.012
槐杞黄颗粒佐治小儿咳嗽变异性哮喘对免疫球蛋白、T 淋巴细胞亚群及细胞因子的影响
Effects of Huaiqihuang Granule on immunoglobul in,T lymphocyte subsets and cytokines in children with cough variant asthma
摘要
Abstract
[ABSTRACT]Objective:To observe the effect of huaiqihuang granule on immunoglobulin,T lymphocyte subsets and cyto-kines in children with cough variant asthma (CVA).Methods:A total of 80 children with CVA enrolled in our hospital were randomly divided into study group and control group.two groups were both given salbutamol aerosol powder,on this basis,the control group were given Montelukast Sodium Chewable Tablets,while the study group were treated with Huaiqihuang gran-ules.,analyze the IL-4,IFN-γ,IgA,IgG and IgE levels and CD4 + ,CD8 + T lymphocyte ratio in children after 3 months of treatment.Results:There were no significant differences between the two groups before treatment (P >0.05 ).Both IgA and IgG were significantly higher in the two groups after treatment,while IgE was significantly lower (P <0.05).Compared with the control group,the IgA and IgG in the study group were significantly higher than those in the control group (P <0.05),IgE was significantly lower (P < 0.05).After treatment,compared with the control group,the proportion of CD4 + and CD4 +/CD8 + in the study group were significantly lower than that of the control group,and the CD8 + ratio increased more significant-ly (P <0.05).After treatment,IL-4 decreased significantly,while IFN-γand IFN-γ/ IL-4 were significantly increased (P <0. 05),IL-4 level of the study group decreased significantly compared with the control group,and IFN-γincreased significantly compared with the control group ,and the level of IFN-γ/IL-4 after treatment was significantly higher than that of the control group (P < 0.05 ).Conclusion:Huaiqihuang granule can improve humoral immunity and cellular immunity of children with CVA,and can adjust the immune cells balance of Th1 /Th2 ,and improve the immune function and prognosis of children with CVA.关键词
槐杞黄颗粒/咳嗽变异性哮喘/免疫球蛋白/T 淋巴细胞亚群/细胞因子Key words
Huaiqihuang granule/Cough variant asthma/Immunoglobulin/T lymphocyte subsets/Cytokines分类
医药卫生引用本文复制引用
张红艳,赵淑景,田菲..槐杞黄颗粒佐治小儿咳嗽变异性哮喘对免疫球蛋白、T 淋巴细胞亚群及细胞因子的影响[J].海南医学院学报,2017,23(3):404-407,4.基金项目
河北省科技支撑计划项目(14196290) （14196290）
