海南医学院学报2017，Vol.23Issue(3)：429-432,4.DOI:10.13210/j.cnki.jhmu.20161115.043
尤瑞克林联合依达拉奉对急性脑梗死患者作用机制的研究
Mechanism of edaravone combined with Urinary Kall idinogenase for acute cerebral infarction
摘要
Abstract
[ABSTRACT]Objective:To observe the effects of edaravone combined with Urinary Kallidinogenase on serum ox-LDL, PCT,hs-CRP,TNF-a and T cell subsets in patients with acute cerebral infarction,so as to explore the mechanisms of combina-tion therapy on patients with acute cerebral infarction.Methods:A total of 86 patients with acute cerebral infarction treated in our hospital from March 2014 to May 201 6 were randomly divided into ontrol group and observation group with 43 cases in each group.All patients were given general treatment according to their own specific conditions,including hypoglycemic,pres-sure adjustment,prevention and treatment of complications,symptomatic support therapy,etc..The control group were given 30 mg Edaravone injection on this basis once per day for 14 days.The observation group was treated with 0.1 5PNA Urinary Kallidinogenase intravenous drip once per day for 14 days based on the treatment of the control group.The levels of serum x-LDL、PCT、hs-CRP、TNF-αand CD3 + 、CD4 + 、CD8 + 、CD4 +/CD8 + were detected and compared between the two groups.Re-sults(1)Before treatment,there was no significant difference between the two groups in the levels of serum ox-LDL、PCT、hs-CRP、TNF-α;after treatment,the serum levels of ox-LDL,PCT,hs-CRP and TNF-αbetween the two groups (P <0.05);(2) Before treatment,there was no significant difference between the two groups in levels of serum CD3 + 、CD4 + 、CD8 + 、CD4 +/CD8 + after treatment,the serum levels of CD3 + ,CD4 + and CD4 +/CD8 + were significantly increased in the two groups,while the level of CD8 + was significantly decreased compared with the same group before treatment,and the difference was signifi-cant(P <0.05);and the levels of serum CD3 + ,CD4 + ,CD8 + and CD4 +/CD8 + in the observation group were significantly higher than those in the control group,and the difference was significant (P <0.05).Conclusion:The treatment of combined application of Urinary Kallidinogenase and edaravone in patients with acute cerebral infarction can significantly improve the ser-um levels of ox-LDL,PCT,hs-CRP,TNF-a and T cell subsets,further illustrates the synergistic effect of the combination, which shows that the two drugs for acute cerebral infarction can inhibit thrombosis to expand,reduce inflammation,relieve cerebral tissue damage,improve neurological function.关键词
急性脑梗死/尤瑞克林/依达拉奉/炎性因子/T 细胞亚群Key words
Acute cerebral infarction/Urinary Kallidinogenase/Edaravone/Inflammatory factor/T cell subsets分类
医药卫生引用本文复制引用
杜春艳,王庆广..尤瑞克林联合依达拉奉对急性脑梗死患者作用机制的研究[J].海南医学院学报,2017,23(3):429-432,4.基金项目
江苏省科技厅基金项目(2015-C-09-26) （2015-C-09-26）
