海南医学院学报2017，Vol.23Issue(4)：440-443,4.DOI:10.13210/j.cnki.jhmu.20161212.004
子痫前期胎盘组织中骨桥蛋白表达量与细胞侵袭、血管新生的关系
Relationship between osteopontin expression and cell invasion as well as angiogenesis in preeclampsia placenta tissue
摘要
Abstract
[ABSTRACT]Objective:To study the relationship between osteopontin expression and cell invasion as well as angiogenesis in preeclampsia placenta tissue.Methods:A total of 56 patients diagnosed with preeclampsia in our hospital between June 2014 and March 201 6 were selected as preeclampsia group (PE group)and 80 normal subjects receiving antenatal examination and giving birth during the same period were selected as control group.After labor,the placenta tissue was collected,immunohis-tochemical staining kits were used to detect OPN expression and enzyme-linked immunosorbent assay kits were used to deter-mine cell invasion and angiogenesis molecule expression.Results:Positive OPN rate in placenta tissue of PE group was signifi-cantly lower than that of control group;cell invasion molecules LAMA4,uPA,Rho and ROCK as well as angiogenesis mole-cules VEGF,PIGF and AGF protein expression in placenta tissue of PE group were significantly lower than those of control group,and cell invasion molecules LAMA4,uPA,Rho and ROCK as well as angiogenesis molecules VEGF,PIGF and AGF protein expression in OPN-positive placenta tissue were significantly higher than those in OPN-negative placenta tissue.Conclu-sions:Lowly expressed OPN in preeclampsia placenta tissue will inhibit the expression of cell invasion molecules and angiogen-esis molecules so as to inhibit sertoli cell invasion and the angiogenesis in placenta tissue.关键词
子痫前期/骨桥蛋白/细胞侵袭/血管新生Key words
Preeclampsia/Osteopontin/Cell invasion/Angiogenesis分类
医药卫生引用本文复制引用
李萍梅,夏俊霞,钟利若..子痫前期胎盘组织中骨桥蛋白表达量与细胞侵袭、血管新生的关系[J].海南医学院学报,2017,23(4):440-443,4.基金项目
深圳市科技计划项目(JCYJ20160422143433757)[Foundation Project]:It was supported by Science and Technology Project of Shenzhen City (No ．JCYJ 20160422143433757)． （JCYJ20160422143433757）
