海南医学院学报2017，Vol.23Issue(4)：448-451,4.DOI:10.13210/j.cnki.jhmu.20161212.007
支气管动脉灌注化疗联合榄香烯对晚期肺癌患者病灶恶性分子及全身免疫应答的影响
Effect of bronchial arterial infusion chemotherapy combined with elemene on the mal ignant lesion molecules and systemic immune response in patients with advanced lung cancer
摘要
Abstract
[ABSTRACT]Objective:To study the effect of bronchial arterial infusion chemotherapy combined with elemene on the ma-lignant lesion molecules and systemic immune response in patients with advanced lung cancer.Methods:A total of 78 patients diagnosed with advanced lung cancer in our hospital between April 2013 and March 201 6 were selected as research subjects and randomly divided into observation group who accepted bronchial arterial infusion chemotherapy combined with elemene therapy and control group who accepted bronchial arterial infusion chemotherapy.After 4 weeks of treatment,tumor lesions were col-lected to determine the expression of proliferation and invasion molecule,and serum was collected to determine the levels of im-mune cell-related cytokines.Results:After 4 weeks of treatment,TCF3,Livin,Bcl-2,HOXB7,PTTG1,Vimentin,E-cad-herin,Rap2a andβ-catenin protein expression in tumor lesions of observation group were significantly lower than those of con-trol group;serum IFN-γlevel of observation group was significantly higher than that of control group while IL-4,IL-9,IL-10 and TGF-βlevels were significantly lower than those of control group.Conclusions:Bronchial arterial infusion chemotherapy combined with elemene can inhibit the expression of proliferation and invasion of molecules in tumor lesions and improve the systemic anti-tumor immune response in patients with advanced lung cancer.关键词
肺癌/榄香烯/支气管动脉灌注化疗/侵袭/增殖Key words
Lung cancer/Elemene/Bronchial arterial infusion chemotherapy/Invasion/Proliferation分类
医药卫生引用本文复制引用
黄浩文,吴轩,潘海东,梁爱芬..支气管动脉灌注化疗联合榄香烯对晚期肺癌患者病灶恶性分子及全身免疫应答的影响[J].海南医学院学报,2017,23(4):448-451,4.基金项目
东莞市医疗卫生一般项目(20151038)[Foundation Project]:It was supported by general medical and health projects of Dongguan City (No ．20151038)． （20151038）
