海南医学院学报2017，Vol.23Issue(4)：464-466,470,4.DOI:10.13210/j.cnki.jhmu.20161205.001
脓毒症患者休克指数与炎症反应、氧化应激反应、靶器官损伤的相关性研究
Correlation between shock index and inflammation,oxidative stress as well as target organ damage in patients with sepsis
摘要
Abstract
[ABSTRACT]Objective:To study the correlation between shock index and inflammation,oxidative stress as well as target organ damage in patients with sepsis.Methods:A total of 70 patients with sepsis treated in our hospital between March 2013 and May 201 6 were collected and divided into no shock group (SI<0.5)(n =1 1),general shock group (0.5≤SI≤2)(n =42) and severe shock group (SI>2.0)(n =1 7)according to the shock index (SI).Immediately after admission,serum levels of in-flammatory factors,oxidative stress indexes and liver function indexes were detected.Results:Serum interleukin-1β(IL-1β), interleukin-8 (IL-8),tumor necrosis factorα(TNF-α),catalase (CAT),advanced oxidation protein products (AOPPs),total bilirubin (TB),γ-glutamyl transpeptidase (GGT)and alanine aminotransferase (ALT)levels of severe shock group and gener-al shock group were higher than those of no shock group while anti-inflammatory factors interleukin-10 (IL-10),interleukin-13 (IL-13),soluble tumor necrosis factor receptor Ⅰ (sTNF-RI),glutathione peroxidase (GSH-Px)and superoxide dismutase (SOD)levels were lower than those of no shock group;serum IL-1β,IL-8,TNF-α,AOPPs,TB,GGT and ALT levels of se-vere shock group were higher than those of general shock group while IL-10,IL-13,sTNF-RI,CAT,GSH-Px and SOD levels were lower than those of general shock group.Conclusions:The higher the shock index in patients with sepsis,the more severe the inflammation,oxidative stress and target organ damage,and the two are positively correlated.关键词
脓毒症/休克指数/炎症反应/氧化应激/靶器官损伤Key words
Sepsis/Shock index/Inflammation/Oxidative stress/Target organ damage分类
医药卫生引用本文复制引用
钟伟州,刘青山,欧远通,高抚刚..脓毒症患者休克指数与炎症反应、氧化应激反应、靶器官损伤的相关性研究[J].海南医学院学报,2017,23(4):464-466,470,4.基金项目
深圳市宝安区社会公益项目(2016CX046)[Foundation Project]:It was supported by Social Welfare Project of Bao＇an District Shenzhen City (No ．2016CX046)． （2016CX046）
