海南医学院学报2017，Vol.23Issue(4)：475-477,481,4.DOI:10.13210/j.cnki.jhmu.20161129.004
胃癌患者幽门螺杆菌感染情况与肿瘤恶性程度的相关性研究
Correlation between hel icobacter pylori infection and tumor mal ignancy in patients with gas-tric cancer
摘要
Abstract
[ABSTRACT]Objective:To study the correlation between helicobacter pylori infection and tumor malignancy in patients with gastric cancer.Methods:A total of 1 1 9 patients with gastric cancer treated in our hospital between May 2013 and Decem-ber 201 5 were collected and divided into HP-positive group (n =89)and HP-negative group (n =30)according to the combina-tion of helicobacter pylori infection or not.RIA method was used to detect the serum angiogenesis index levels;fluorescence quantitative PCR (RT-PCR)was used to detect the mRNA expression of autophagy genes and proliferation genes in tumor tis-sues.Results:Serum angiogenesis indexes bFGF,VEGF and MMP-9 levels of HP-positive group were significantly higher than those of HP-negative groups;autophagy genes Beclin1,BNIP3,pULK and PI3KC3 mRNA expression in tumor tissues of HP-positive group were significantly lower than those of HP-negative group,pro-apoptotic genes Bax and p53 mRNA expression were significantly lower than those of HP-negative group,and anti-apoptotic genes PIK3CD,CIP2A and I2PP2A mRNA ex-pression were significantly higher than those of HP-negative group.Conclusions:Helicobacter pylori infection can promote an-giogenesis and cell proliferation in lesions of patients with gastric cancer.关键词
胃癌/幽门螺杆菌/增殖基因/侵袭基因Key words
Gastric cancer/Helicobacter pylori infection/Proliferation gene/Invasion gene分类
医药卫生引用本文复制引用
陈晓兵..胃癌患者幽门螺杆菌感染情况与肿瘤恶性程度的相关性研究[J].海南医学院学报,2017,23(4):475-477,481,4.基金项目
鄂州市科技成果项目(1000970108) （1000970108）
