海南医学院学报2017，Vol.23Issue(4)：497-500,4.DOI:10.13210/j.cnki.jhmu.20161201.005
血液透析联合血液灌流对尿毒症患者透析效率、脂代谢及动脉粥样硬化的影响
Effect of hemodialysis combined with hemoperfusion on dialysis efficiency,l ipid metabol ism and atherosclerosis in patients with uremia
摘要
Abstract
[ABSTRACT]Objective:To study the effect of hemodialysis (HD)combined with hemoperfusion (HP)on dialysis effi-ciency,lipid metabolism and atherosclerosis in patients with uremia.Methods:A total of 70 patients with uremia who were treated in our hospital between March 2013 and October 201 5 were collected and divided into observation group and control group (n =35)according to double-blind randomized control method.Observation group of patients received hemodialysis com-bined with hemoperfusion,control group of patients received hemodialysis alone,and the treatment lasted for 6 months.After 6 months of intervention,automatic biochemical analyzer was used to detect renal function indexes and lipid metabolism inde-xes,and the two-dimensional ultrasound was used to quantitatively determine the carotid atherosclerosis parameters.Results:Before intervention,differences in renal function,lipid metabolism and atherosclerosis levels were not statistically significant between two groups of patients (P >0.05);after 6 months of intervention,renal function indexes blood urea nitrogen (BUN), serum creatinine (Scr),β2-microglobulin (β2-MG)and blood uric acid (BUA)levels of observation group were lower than those of control group,lipid metabolism indexes total cholesterol (TC),triglyceride (TG),apolipoprotein A1 (ApoA1)and apolipoprotein B (ApoB)levels were lower than those of control group,and differences between groups were statistically sig-nificant (P <0.05);quantitative carotid ultrasound parameters gray-scale median (GSM)of observation group was higher than that of control group,enhanced intensity (EI)and enhanced density (ED)were lower than those of control group,and differ-ences between groups were statistically significant (P < 0.05 ).Conclusions:Hemodialysis combined with hemoperfusion can improve the dialysis efficiency,also reduce lipid metabolism disturbance and delay the formation of atherosclerosis in patients with uremia.关键词
尿毒症/血液透析/血液灌流/肾功能/动脉粥样硬化Key words
Uremia/Hemodialysis/Hemoperfusion/Renal function/Atherosclerosis分类
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唐俊,左满花..血液透析联合血液灌流对尿毒症患者透析效率、脂代谢及动脉粥样硬化的影响[J].海南医学院学报,2017,23(4):497-500,4.基金项目
湖北省教育厅中青年人才项目(Q20161905)[Foundation Project]:It was supported by Young Talent Project of Department of Education in Hubei Province (No ．Q20161905)． （Q20161905）
