海南医学院学报2017，Vol.23Issue(4)：514-517,4.DOI:10.13210/j.cnki.jhmu.20161201.002
抗 CCP 抗体、补体及免疫球蛋白在类风湿性关节炎病理过程中的变化及临床意义
Cl inical significance of detection of anti-CCP antibodies,complement and immunoglobul in in patients with rheumatoid arthritis
摘要
Abstract
[ABSTRACT]Objective:To detect the serum levels of anti-Cyclic Citrullinated Peptide (CCP)antibodies,complement (C3 and C4 )and immunoglobulin (IgG,IgA and IgM)in patients with rheumatoid arthritis (RA).Methods:A total of 100 patients with RA were selected as the observation group,and 60 healthy people were selected as the control group.The RA patients were divided into the high disease active group (25 cases),moderate disease active group (30 cases),low disease active group (24 cases)and remission group (21 cases)according to the disease activity score in 28 joints (DAS28 score).The levels of anti-CCP antibodies,C3 ,C4 ,IgG,IgA and IgM of each research object were detected.Difference of all the serum indexes between the observation group and control group were compared,as well as that between the RA patients in different disease activity states.Finally,the correlation of anti-CCP antibodies with C3 ,C4 ,IgG,IgA and IgM were analyzed.Results:(1)The levels of anti-CCP antibodies [(67.75±21.28)U/mL],C3 [(1.95±1.14)g/L],C4 [(0.63±0.22)g/L],IgG [(18.77±4.83)g/L], IgA [(4.74±1.06)g/L]and IgM [(4.02±0.98)g/L]in the observation group were obviously higher than that in the control group (P <0.05).(2)Compared with RA in remission,the levels of anti-CCP antibodies,C3 ,C4 ,IgG,IgA and IgM of RA in activity were significant higher (P < 0.05 ).Compared with the low disease active group,the levels of anti-CCP antibodies [(73.83±5.28)U/mL and (86.50±6.39)U/mL],C3 [(2.24±0.18)g/L and (2.35±0.20)g/L],C4 [(0.70±0.1 1)g/L and (0.74±0.09)g/L],IgG [(1 9.65±3.02)g/L and (21.30±2.44)g/L],IgA [(5.64±1.25)g/L and (6.00 ±1.13)g/L]and IgM [(4.42±0.94)g/L and (4.83 ±0.77)g/L]in the moderate and high disease active groups were obviously higher (P <0.05).And the anti-CCP antibodies levels in the high disease active group were significantly higher than that in the moderate ones (P <0.05).The anti-CCP antibodies in RA patients had significant positive correlation with C3 ,C4 ,IgG,IgA and IgM (r=0.462,0.554,0.558,0.772,0.741,P <0.05).Conclusions:The levels of anti-CCP antibodies,C3 ,C4 ,IgG,IgA and IgM in RA patients were increased obviously,and they were correlated with the disease activity of RA.They could be important inde-xes for the diagnosis and illness monitoring of RA.关键词
类风湿性关节炎/抗环瓜氨酸肽抗体/补体/免疫球蛋白Key words
Rheumatoid arthritis/Anti-cyclic citrullinated peptide antibodies/Complement/Immunoglobulin分类
医药卫生引用本文复制引用
肖雪野..抗 CCP 抗体、补体及免疫球蛋白在类风湿性关节炎病理过程中的变化及临床意义[J].海南医学院学报,2017,23(4):514-517,4.基金项目
四川省科技厅应用基础项目(2015K27-021).[Foundation Project]:It was supported by Application Foundation Project of Science and Technology Department of Sichuan Province (No ．2015K27-021)． （2015K27-021）
