海南医学院学报2017，Vol.23Issue(4)：539-541,545,4.DOI:10.13210/j.cnki.jhmu.20161216.013
乳腺癌改良根治术后胸壁加锁骨野常规放疗与三维适形放疗的疗效及安全性分析
Efficacy and safety of conventional radiotherapy of chest wall and clavicular field and three-dimensional conformal radiotherapy in patients after modified radical mastectomy
摘要
Abstract
[ABSTRACT]Objective:To explore the efficacy and safety of conventional radiotherapy of chest wall and clavicular field and three-dimensional conformal radiotherapy in patients after modified radical mastectomy.Methods:A total of 84 patients who were admitted in our hospital after modified radical mastectomy were included in the study and divided into the convention-al radiotherapy group (n =42)and the three-dimensional conformal radiotherapy group (n =42)according to different radio-therapy methods.The patients in the conventional radiotherapy group were given conventional radiotherapy of chest wall and clavicular field,while the patients in the three-dimensional conformal radiotherapy group were given three-dimensional confor-mal radiotherapy.The serum tumor markers and peripheral blood T lymphocyte subsets 6~8 weeks after treatment in the two groups were detected.The clinical efficacy,and toxic and side effects in the two groups were evaluated.Results:The serum CA1 5-3,CA125,CEA,and CK1 9 levels after treatment in the two groups were significantly reduced when compared with be-fore treatment (P <0.05),CD3 + ,CD4 + ,and CD4 +/CD8 + were significantly elevated,while CD8 + was significantly reduced when compared with before treatment (P <0.05),but the comparison of the above indicators between the two groups was not statistically significant (P >0.05).The occurrence rate of radioactive skin damage and pneumonia after treatment in the con-ventional radiotherapy group was significantly higher than that in the three-dimensional conformal radiotherapy group (P <0.05).Conclusions:The two kinds of radiotherapy schemes have an equal efficacy,but the toxic and side effects of three-dimen-sional conformal radiotherapy are significantly lower than those by the conventional radiotherapy,with a certain advantage.关键词
乳腺癌/常规放疗/三维适形放疗/肿瘤标志物/T 淋巴细胞亚群Key words
Breast cancer/Conventional therapy/Three-dimensional conformal radiotherapy/Tumor markers/T lym-phocyte subsets分类
医药卫生引用本文复制引用
王松林,潘金华,童武松..乳腺癌改良根治术后胸壁加锁骨野常规放疗与三维适形放疗的疗效及安全性分析[J].海南医学院学报,2017,23(4):539-541,545,4.基金项目
湖北省钟祥市科学技术支撑项目(0910108144)[Foundation Project]:The study was supported by the Scientific and Technological Support Project of Zhongixang City in Hubei Province with the number of 0910108144． （0910108144）
