郑州大学学报（医学版）2017，Vol.52Issue(1)：13-16,4.DOI:10.13705/j.issn.1671-6825.2017.01.004
婴儿双歧杆菌对 ConA 诱导小鼠肝纤维化的影响
Effect of infant bifidobacteria on liver fibrosis of mice induced by ConA
摘要
Abstract
Aim:To research the preventive effects and mechanism of infant bifidobacteria on liver fibrosis of mice in -duced by concanavalin A(ConA).Methods: The mice were randomly allocated into three groups: normal group, model group and infant bifidobacteria-treated group,12 in each group.The ConA solution(12.5 mg/kg) was given by intravenous injection to the model group and infant bifidobacteria-treated group once a week , normal group and model group were given normal saline by gavage ,and infant bifidobacteria-treated group was given infant bifidobacteria (0.5 g/kg) by gavage once a day.After 7 weeks, liver weight index, liver function, concentrations of HA and PCⅢin serum, as well as collagen Ⅰ, collagen Ⅲ, MMP-1, MMP-2, MMR-9, TIMP-1,TNF-α, IL-6, IL-10 in liver tissue were determined .Results: Infant bifidobacteria could decrease liver weight index (P<0.05), improve the liver function(P<0.05), decrease the serum concentrations of HA and PC Ⅲ(P<0.05), decrease the contents of collagen Ⅰ, collagen Ⅲ, MMP-2, MMR-9, TIMP-1,TNF-α, IL-6(P<0.05) in mice liver tissue, and increase the contents of MMP-1 and IL-10 in mice liver tissue(P<0.05).Conclusion:Infant bifidobacteria could prevent liver fibrosis of mice induced by ConA .关键词
婴儿双歧杆菌/小鼠/肝纤维化/刀豆蛋白Key words
infant bifidobacteria/mouse/liver fibrosis/concanavalin分类
医药卫生引用本文复制引用
刘超,郭琦,郑鹏远,刘霞,于泳,唐芙爱,赵治国..婴儿双歧杆菌对 ConA 诱导小鼠肝纤维化的影响[J].郑州大学学报（医学版）,2017,52(1):13-16,4.基金项目
国家自然科学基金资助项目81370494；郑州市科技领军人才项目131PLIRC656 （）
