郑州大学学报（医学版）2017，Vol.52Issue(1)：17-19,20,4.DOI:10.13705/j.issn.1671-6825.2017.01.005
环丙沙星和左氧氟沙星对豚鼠右心室乳头肌动作电位的影响
Effects of ciprofloxacin and levofloxacin on cardiac action potential in right ventricle papillary muscles of guinea pigs
摘要
Abstract
Aim:To examine the effects of ciprofloxacin ( CIP) and levofloxacin ( LVFX) on cardiac action potentials in right ventricle papillary muscles of guinea pigs .Methods:The right ventricle papillary muscles of guinea pigs were trea-ted with oxygen-saturated Tyrode continuous perfusion .Cumulative concentration dosing method was used to join CIP or LVFX in perfusion and the drug concentration in turn reached to 0,1,10 and 100 μmol/L.The time of resting potential (RP),amplitude of action potential(APA),action potential duration of 50%repolarization(APD50) and APD90 were recor-ded by conventional microelectrode techniques .Sparfloxacin ( SPX) was the positive control , and 6 pigs in each group .Re-sults:The three drugs had no effect on RP or APA(P>0.05).SPX could prolong APD50 and APD90, and the effects en-hanced with the concentration increasing (P<0.001).LVFX could not prolong APD50 (P=0.110), but could prolong APD90, and this effect enhanced with the increase of the concentration (P<0.001).CIP had no effect on APD50,and could extend APD90 only at dose of 100μmol/L(P=0.002).Conclusion:CIP and LVFX at large dose could prolong the action potential duration of right ventricle papillary muscles of guinea pigs , and have potential cardiac toxicity .关键词
环丙沙星/左氧氟沙星/右心室乳头肌/动作电位/豚鼠Key words
ciprofloxacin/levofloxacin/right ventricle papillary muscle/action potential/guinea pig分类
医药卫生引用本文复制引用
刘芳,乔蕾,陈文超,孔春艳..环丙沙星和左氧氟沙星对豚鼠右心室乳头肌动作电位的影响[J].郑州大学学报（医学版）,2017,52(1):17-19,20,4.基金项目
河南省基础与前沿技术研究计划项目142300410469；河南省高等学校青年骨干教师资助计划项目2014GGJS-199 （）
