郑州大学学报（医学版）2017，Vol.52Issue(1)：20-24,5.DOI:10.13705/j.issn.1671-6825.2017.01.006
基于超高效液相-质谱联用技术的淋巴瘤患者血浆代谢组学分析
Ultra high performance liquid chromatography-mass spectrometry based plasma metabonomics for patients with lymphoma
摘要
Abstract
Aim:To explore the potential biomarkers of lymphoma .Methods:Ultra high performance liquid chroma-tography-Q Exactive orbit trap high-resolution mass spectrometry was applied to process the plasma samples of 12 lymphoma patients as well as 12 healthy volunteers .Orthogonal to partial least squares discriminant analysis was performed to identify the differences in metabolic profiles between the two groups and further to select potential biomarkers related to lymphoma . Results:A significant distinction in the metabolic profiles between lymphoma patients and healthy volunteers was yielded by multivariate statistical analysis and 8metabolites were found .Compared with healthy controls , the contents of aspartic acid and 4-pyridoxate were significantly higher in plasma of lymphoma patients (P<0.05), while the contents of L-α-glyc-erophosphorylcholine ,linoleic acid ,decanoyl carnitine ,phenylalany-lphenylalanine ,taurine and threonic acid were obviously lower(P<0.05).Conclusion:The 8 metabolites found via metabonomics might be potential biomarkers associated to lym-phoma.关键词
超高效液相色谱-质谱联用/代谢组学/淋巴瘤/生物标志物Key words
UPLC-MS/metabonomics/lymphoma/biomarker分类
医药卫生引用本文复制引用
姚珂,杜正,刘瀛,徐少博,左非非,魏双艳,徐晓阳,徐霞..基于超高效液相-质谱联用技术的淋巴瘤患者血浆代谢组学分析[J].郑州大学学报（医学版）,2017,52(1):20-24,5.基金项目
河南省基础与前沿技术研究计划项目142300410085 （）
