郑州大学学报（医学版）2017，Vol.52Issue(1)：25-28,4.DOI:10.13705/j.issn.1671-6825.2017.01.007
腺苷 A2 A受体对新生小鼠离体延髓脑片基本节律性呼吸放电的调节作用
Effects of adenosine A2A receptor on basic rhythmic respiration discharge activity of medulla oblongata slice from neonatal mice in vitro
摘要
Abstract
Aim:To investigate the effect of adenosine A 2A receptor on basic rhythmic respiratory discharge activity ( RRDA) of medulla oblongata slice from neonatal mice .Methods: Medulla oblongata slices in vitro from neonatal mice were prepared, and then perfused with artificial cerebrospinal fluid (ACSF) which containing 0.0, 2.5, 5.0, 10.0, 20.0 nmol/L adenosine A2A receptor agonist CGS21680 or antagonist SCH58261 for 10 min.At the 6th min of perfusion, ad-sorption electrode was used to record the inhale duration (TI), discharge integral amplitude (IA) and respiratory cycle (RC).Results:CGS21680 could shorten RC, increase TI and IA(P<0.001), excite RRDA;SCH58261 could extend RC, reduce TI and IA(P<0.001),and has inhibitory effect on RRDA.Conclusion: The adenosine A2A receptor may play an excitatory role in RRDA of medulla oblongata in neonatal mice .关键词
腺苷A2 A受体/新生小鼠/延髓脑片/基本节律性呼吸放电Key words
adenosine A2A receptor/neonatal mouse/medulla oblongata slice/basic rhythmic respiratory discharge ac-tivity分类
医药卫生引用本文复制引用
闫思涵,刘友才,千智斌..腺苷 A2 A受体对新生小鼠离体延髓脑片基本节律性呼吸放电的调节作用[J].郑州大学学报（医学版）,2017,52(1):25-28,4.基金项目
河南省科技厅重点攻关项目102102310156；新乡市科技局重点攻关项目 ZG14004 （）
