郑州大学学报（医学版）2017，Vol.52Issue(1)：41-44,4.DOI:10.13705/j.issn.1671-6825.2017.01.011
Toll样受体在大鼠大脑皮层发育过程中的表达
Expressions of Toll-like receptors in development of rat cerebral cortex
摘要
Abstract
Aim:To observe the changes of Toll-like receptor ( TLR) expression in the differentiation and maturation of the rat brain.Methods:Cerebral cortex of fetal rats of 16 and 18 days and neonatal rats(n=10) were collected to detect Ki-67 and NeuN by fluorescent antibody , TLR expression by real-time PCR and Western blot method .Results:With the development of the progress , the percentages of NeuN positive cells and Ki-67 positive cells in the rat cerebral cortex de-creased gradually(P<0.05), the expressions of TLR1, TLR2, TLR3, TLR4, TLR7 and TLR9 increased gradually(P<0.05), while the expressions of TLR5, TLR6 and TLR8 had no significant changes(P>0.05).Conclusion:TLR may be involved in the differentiation and maturation of neural progenitor cells .关键词
TLR/大脑皮层/大鼠/大脑发育Key words
Toll-like receptor/cerebral cortex/rat/cerebral development分类
医药卫生引用本文复制引用
靳玫,刘晓利,唐超智,宿俊杰,崔俊伟,王文晟..Toll样受体在大鼠大脑皮层发育过程中的表达[J].郑州大学学报（医学版）,2017,52(1):41-44,4.基金项目
国家自然科学基金面上项目31170733 （）
