郑州大学学报（医学版）2017，Vol.52Issue(1)：63-67,5.DOI:10.13705/j.issn.1671-6825.2017.01.017
血浆可溶性血管内皮生长因子受体1在重症肺炎患者中的诊断与预测价值
Diagnosis and predictive value of plasma soluble vascular endothelial growth factor receptor-1 in patients with severe pneumonia
摘要
Abstract
Aim:To explore the diagnosis and predictive value of plasma soluble vascular endothelial growth factor re -ceptor-1(sFLT-1) in patients with severe pneumonia.Methods:A total of 60 patients with severe pneumonia(group A), 60 patients with severe pneumonia-related septic shock ( group B ) and 60 patients with severe pneumonia-related MODS (group C) in RICU of Affiliated Zhengzhou Central Hospital of Zhengzhou University were admitted from October 2013 to April 2016 in the study .Sixty cases of common community-acquired pneumonia in Department of Respiratory Medicine were included for comparison(group D).Plasma sFLT-1 was measured on the 1st,3rd and 7th day respectively.The association of sFLT-1 with APACHE Ⅱ score and predictive value of sFLT-1 for severe pneumonia were analyzed .Results: The differences were significant in the levels of PCT and APACHE Ⅱscore among the 4 groups(P<0.05).There were signifi-cant differences in plasma sFLT-1 among group A,B and C, and sFLT-1 was the lowest on the 7th day in group A,B and C (P<0.05).Non-survivors of severe pneumonia had higher plasma sFLT-1 levels than survivors(P<0.001).Plasma sFLT-1 level correlated with the APACHE Ⅱscore(r=0.647,P<0.001).sFLT-1 was used for diagnosis of severe pneu-monia and predict the mortality for 28 d,and the sensitivity and the specificity was 77.8%,75.0% and 69.7%,80.1%, respectively.AUC was 0.787(95%CI =72.6% -84.8%,P<0.001)and 0.775(95%CI =70.5% -84.5%,P <0.001),respectively.Conclusion:Plasma sFLT-1 level could predict severe pneumonia and mortality for 28 d.关键词
血浆可溶性血管内皮生长因子受体1/重症肺炎/预测价值Key words
plasma soluble vascular endothelial growth factor receptor-1/severe pneumonia/predictive value分类
医药卫生引用本文复制引用
高延秋,张华,李双凤,董睿,李振华,任英杰..血浆可溶性血管内皮生长因子受体1在重症肺炎患者中的诊断与预测价值[J].郑州大学学报（医学版）,2017,52(1):63-67,5.基金项目
河南省医学科技攻关项目201503210 （）
