华南农业大学学报2017，Vol.38Issue(2)：18-21,4.DOI:10.7671/j.issn.1001-411X.2017.02.004
盐酸氯苯胍在兔体内的药动学及生物利用度研究
Studies on pharmacokinetic and bioavailability of robenidine hydrochloride in rabbits
摘要
Abstract
[Objective] To investigate the pharmacokinetics and bioavailability after oral administration of the coccidiostat , robenidine hydrochloride in rabbits .[Method] A total of 16 healthy New Zealand white rabbits were allotted to two groups and received single intravenous administration of robenidine hydrochlo -ride at the dose of 2.00 mg· kg -1 and single oral administration at the dose of 100.00 mg· kg -1 respec-tively.Blood samples were collected and analyzed by high-performance liquid chromatography ( HPLC) using UV.Pharmacokinetic parameters were estimated using the Winnonlin TM software package and the curve of time and concentration was obtained using SPSS 16.0.[Result]After i.v.injection, area under the concentration-time curve ( AUC ) was 1.72 μg · h · mL-1 , plasma clearance ( CI ) was 1.17 L· h-1 · kg -1 , the volume of distribution was 2.87 L· kg -1 and the half-life of elimination ( t1/2 ) was 1.72 h.After oral administration , t1/2 was 8.94 h and AUC was 6.33μg· h· mL-1 .Statistical analysis showed that there were significant differences between pharmacokinetic parameters of intravenous and oral administration ( P <0.05 ) , and the bioavailability following oral administration was low ( 7.36%) .[Conclusion]The volume of distribution following robenidine hydrochloride was high , suggesting that the drug was widely distributed in rabbits and eliminated rapidly;Robenidine hydrochloride for oral adminis-tration was rarely absorbed into the blood or blood circulation , and the residues in vivo was low .关键词
盐酸氯苯胍/药物代谢动力学/生物利用度/新西兰大白兔Key words
robenidine hydrochloride/pharmacokinetic/bioavailability/rabbit分类
农业科技引用本文复制引用
李强,谢顺,曾松情,李洁,徐尤发,张申,黄显会..盐酸氯苯胍在兔体内的药动学及生物利用度研究[J].华南农业大学学报,2017,38(2):18-21,4.基金项目
农业行业标准制定与修订项目 （）
