中国实用神经疾病杂志2017，Vol.20Issue(2)：5-8,4.
脑梗死合并脑白质疏松相关因素分析
Correlation factor analysis of cerebral infarction complicated with leukoaraiosis
摘要
Abstract
Objective To explore the main pathogenic factors and pathogenesis of leukoaraiosis (LA)for the purpose of reducing its incidence and preventing cerebral infarction .Methods The selected inpatients with cerebral infarction in the de‐partment of neurology in our hospital from October 2013 to October 2015 were collected continuously .According to the typical imaging changes ,cases were divided into LA group and non-LA group .The possible risk factors were compared between two groups .The data were analyzed by SPSS 17.0 and S-PLUS 8.0 .First ,the possible risk factors were analyzed by univariate a‐nalysis ,and then Logistic regression was used in multivariate analysis .The relationship between the severity of LA and the screened factors were compared .Results Univariate analysis of the risk factors showed that the differences in age ,body mass index ,coronary heart disease ,hemoglobin ,homocysteine cevebral infarction subtype were statistically significant between the two groups(all P<0.05) .Then the multivariate Logistic analysis revealed that age(OR=1.142 ,95% CI:1.052 to 1.239 ,P=0.001)and homocysteine (OR = 1.212 ,95% CI:1.023 to 1.436 ,P = 0.026)were the independent risk factors for LA. Additionally ,the additive interaction of Bootstrap estimation method for confidence intervals revealed that both age and ho‐mocysteinehadadditiveinteractionswithLA[RERI=0.01487(95% CI:0.00032to0.06115),AP=0.01114(95% CI:0.000 61 to 0.035 63) ,S=1.047(95% CI:1.012 70 to 1.081 76)] .Furthermore ,Logistic regression analysis on ordinal multi-classi‐fication data revealed that the older they grew ,the more seriously the degree of LA (β=0.093 ,95% CI:0.056 to 0.129 ,P=0.000) ,and the lower the MMSE scores(β= -0.137 ,95% CI:-0.189 to -0.085 ,P=0.000) .Conclusion Firstly ,age and homocysteine are the two independent risk factors for LA .Secondly ,age and homocysteine have positive additive interactions with LA ,namely the combined effect of these two factors is greater than the sum of the single effects .Thirdly ,the older they grow ,the more seriously the degree of LA .Fourthly ,the more serious the degree of LA is ,the more obvious cognitive impair‐ment .Finally ,the pathogenesis of LA remains unclear ,which may be related to cerebral small vessel diseases .关键词
脑白质疏松/同型半胱氨酸/脑梗死Key words
Leukoaraiosis/Homocysteine/Cerebral infarction分类
医药卫生引用本文复制引用
张捷,陈海亮,许多,张林艳,周杜娟..脑梗死合并脑白质疏松相关因素分析[J].中国实用神经疾病杂志,2017,20(2):5-8,4.基金项目
福州市卫生局青年科研项目 （）
