湖南中医药大学学报2017，Vol.37Issue(1)：18-21,4.DOI:10.3969/j.issn.1674-070X.2017.01.004
复方柴金解郁片抗抑郁作用的实验研究
Study on Anti-depressant Effect of Compound Chaijin Jieyu Tablet
摘要
Abstract
Objective Preliminary study on the anti-depressant effect of compound Chaijin Jieyu tablet (CJJY). Methods Two kinds of mice models of depression were established, the mice forced swimming test and hanging tail test replication stress behavioral despair models of depression, serotonin acid and reserpine induced drug-induced depression model; detection of mouse forced swimming test and the tail suspension test in the time of immobility, serotonin acid induced depression in mice the number of head twitches, reserpine induced depression of body temperature, eyelid closure, akinesi-a difference degree of mice. Results Compared with the control group, the immobility time of 4 times and 2 times or (1 times) dose CJJY groups by the forced swimming test and tail suspension test in mice was significantly reduced (P<0.05). Compared with the control group, the head-twitching number of 4 times and 2 times dose CJJY group, in 5-HT acid in-duced head twitches test, was significantly increased (P<0.05 or P<0.01). In the experiment of depression induced by reser-pine, compared with the control group, the number of mice in the model group, which the eyelids were unable to open 1/2 and akinesia, was significantly increased. After 1h and 4 h, the body temperature of the rest mice was decreased (P<0.01 or P<0.05). Compared with model group, the number of mice in the CJJY 4 times and 2 times dose groups, which the eyelids were unable to open 1/2 and akinesia. was significantly decreased. After 1h and 4h, the body temperature of the rest mice in each group was increased (P<0.01 or P<0.05). Conclusion CJJY shows obvious anti-depression effect on all kinds of depression mouse models.关键词
复方柴金解郁片/抗抑郁/强迫游泳实验/悬尾实验/五羟色胺酸诱导实验/利血平诱导实验Key words
compound Chaijin Jieyu tablet/anti-depression/forced swimming test/hanging tail test/5-HT acid inducing test/reserpine inducing test分类
医药卫生引用本文复制引用
韩远山,蔺晓源,邵乐,杨蕙,王宇红,杜青,孟盼..复方柴金解郁片抗抑郁作用的实验研究[J].湖南中医药大学学报,2017,37(1):18-21,4.基金项目
国家自然科学基金青年项目 （）
湖南省科技厅重点项目（2015DK3003）。 （）
