湖南中医药大学学报2017，Vol.37Issue(1)：29-32,4.DOI:10.3969/j.issn.1674-070X.2017.01.007
饥饿程度对大鼠学习记忆能力影响的实验研究
Experimental Research on the Effect of Different Degree of Hunger on Learning and Memory Ability in Rats
摘要
Abstract
〔Abstract〕 Objective To explore the effect of different degree of hunger on spatial learning and memory ability of rats. Methods 84 healthy adult male SD rats were randomly divided into eight groups. The groups of A to G are treated with hunger for 6, 18 , 24, 30, 36, 42 h. The group H is treated as control. In addition, an experiment is carried out every six hours to group A and group H. The Morris Water Maze was used to conduct the behavior training of SD male rats, in-cluding its effects on spatial learning and memory ability of rats. Results (1) The escape latency of the A to G groups treated with different degree of hunger decrease firstly then increase in the place navigation test. The number of times for rats cross the original platform and the percentage of target quadrant retention time of the A to G group in the spatial probe test in-crease firstly and then decrease. The group of hunger for 24 h VS control group:(22.58±4.44) s VS (29.23±6.81) s, P<0.01;The group of hunger for 36 h VS control group: (35.58±4.89) s VS (29.23±6.81) s, P<0.05. The frequency of crossing the o-riginal platform in the spatial probe test have a downward trend after slowly rising, the group of hunger for 24 h VS con-trol: group (3.18±0.72) times VS (2.33±0.67) times, P<0.05; the group of hunger for 42 h VS control group: (1.64±0.64) times VS (2.33±0.67) times, P<0.05. The percentage of target quadrant retention time in the spatial probe test also have a downward trend after slowly rising, the group of hunger for 24 h VS control group: (40.06±3.65)% VS (33.64±4.55)%, P<0.05; the group of hunger for 42 h VS control group: (26.70±4.50)% VS (33.64±4.55)%, P<0.05. (2) The escape latency of group G treated by continuously hunger shows the tendency of decrease slowly after the first increase in the place navigation test, the group of hunger continuously for 6 h VS the group of hunger continuously for 24 h:(28.74 ±5.24) s VS (20.88 ±4.30) s, P<0.01;the group of hunger continuously for 6 h VS the group of hunger continuously for 30 h:(28.74±5.24) s VS (19.97±6.14) s, P<0.01. Conclusion Short-term hunger (12 h and 18 h) contributes to improve the ability of spatial learning and memory of rats. Hunger for a long time (36 h and 42 h) could decline the ability of spatial learning and memory of rats.关键词
饥饿/Morris水迷宫/空间探索/定位航行/学习能力/记忆能力Key words
hunger/Morris water maze/spatial learning and memory/place navigation/learning ability/memory ability分类
医药卫生引用本文复制引用
李状,陈佳雪,罗佳辉,王洁,王启超,谢静涛..饥饿程度对大鼠学习记忆能力影响的实验研究[J].湖南中医药大学学报,2017,37(1):29-32,4.基金项目
2014年度湖南省大学生研究性学习和创新性实验计划项目。 （）
