海洋科学2016，Vol.40Issue(11)：108-112,5.DOI:10.11759/hykx20160413001
海洋溴酚化合物BDDPM促进肝糖原合成及缓解胰岛素抵抗的作用研究
A study on hepatic glycogen synthesis and insulin resistance of marine derived bromophenol BDDPM
摘要
Abstract
Bis (2, 3-dibromo-4, 5-dihydroxy-phenyl)-methane (BDDPM) is a bromophenol compound with a new structure extracted from the marine red algae Rhodomela confervoides. A previous study showed that BDDPM could significantly inhibit PTP1B activity in vitro. In this research, we studied the effect of BDDPM on hepatic glycogen synthesis ability and insulin resistance in HepG2 and C2C12 cells. The results reveal that 1-μM BDDPM can significantly activate insulin signaling, enhance hepatic glycogen synthesis, and alleviate PA-induced insulin resistance. As such, BDDPM has the potential to be developed as an anti-diabetic agent.关键词
松节藻/BDDPM/T2DM/糖原合成/胰岛素抵抗Key words
Rhodomela confervoides/BDDPM/T2DM/glycogen synthesis/insulin resistance分类
医药卫生引用本文复制引用
罗娇,徐琦,王立军,江波,史大永..海洋溴酚化合物BDDPM促进肝糖原合成及缓解胰岛素抵抗的作用研究[J].海洋科学,2016,40(11):108-112,5.基金项目
国家自然科学基金面上项目(41276167) （41276167）
山东省重点研发计划(2015GGF01039) （2015GGF01039）
青岛市基础研究计划项目(No.14-2-4-35-jch) （No.14-2-4-35-jch）
国家高层次人才特支计划“万人计划” （）
国家海洋实验室“鳌山人才计划” （）
