摘要
Abstract
Objective To investigate the relativity between Lown’s classification of premature ventricular contraction(PVC)and the severity of myocardial fibrosis in hypertrophic cardiomyopathy (HCM)patients.Methods Fifty-nine HCM patients underwent cardiac magnetic resonance scan-ning and 24 h Holter examination,thereby we obtained late gadolinium enhancement(LGE,charac-terizing the severity of myocardial fibrosis)and the occurrence of PVC.The patients were grouped by Lown’s classification and myocardial LGE was compared.By Spearman correlation analysis,the relativity between LGE and the severity of PVC was analyzed.Results PVC occurred in 43 patients (72.88%).According to Lown's classification,there were 1 6 patients in grade 0,6 in grade 1 ,3 in grade 2,1 8 in grade 3 and 1 6 in grade 4.The LGE rate,total LGE volume and total LGE mass of grade-4 patients were (34.05 ±1 4.53)%,(66.33 ±29.96)mL and (66.81 ±30.35)g,re-spectively,all significantly higher than those of grade-0 3 patients(P <0.05).The above values of grade-3 patients were separately (26.86 ±1 2.91 )%,(38.62 ±25.23)mL and (36.98 ± 24.06)g,all significantly higher than those of grade-0 2 patients but significantly lower than those of grade-4 patients(P <0.05 ).The above values of grade-0 patients were separately (1 5.93 ± 1 1 .35)%,(1 8.62 ±1 6.1 9)mL and (1 7.64 ±1 5.40)g,all significantly lower than those of grade-1 4 patients(P <0.05).The LGE rate,total LGE volume and total LGE mass were all posi-tively correlated with Lown’s classification(correlation coefficient r =0.639,0.640 and 0.551 ,re-spectively;P <0.000 1 ).Conclusion The severity of PVC in HCMpatients were positively corre-lated with the degree of myocardial fibrosis.The higher the grade of Lown’s classification,the more severe the degree of myocardial fibrosis.关键词
肥厚型心肌病/室性早搏/心肌纤维化/延迟强化Key words
hypertrophic cardiomyopathy/premature ventricular contraction/myocardial fibro-sis/late gadolinium enhancement分类
医药卫生
