检验医学与临床2017，Vol.14Issue(3)：314-316,3.DOI:10.3969/j.issn.1672-9455.2017.03.002
慢性乙型肝炎患者病程转归与凝血功能相关指标分析
The relationship between the function of blood coagulation and clinical classification in patients with hepatitis B
摘要
Abstract
Objective To investigate the relationship between the function of blood coagulation and clinical classification in pa-tients with hepatitis B .Methods A total of 263 patients with hepatitis B were collected in this study ,which were divided into four groups ,89 cases in chronic hepatitis B group ,91 cases in liver cirrhosis group ,44 cases of in liver failure group ,39 cases in liver cancer group .STA-R Evolution automatic blood coagulation analyzer was used to detect prothrombin time (PT ) ,activated coagula-tion time of whole blood(APTT) ,fibrinogen(FIB) ,thrombin time(TT) ,antithrombin-Ⅲ(AT-Ⅲ) ,D-dimer(D-D) and fibrin degra-dation products(FDP) ,then the values of PT ,APTT ,FIB ,TT ,AT-Ⅲ ,D-D and FDP in four groups were compared .Results In the chronic hepatitis B group ,PT[(14 .63 ± 0 .22)s] ,D-D[(765 .3 ± 129 .7)mg/L]and FDP[(1 .75 ± 0 .42)mg/mL] were significant lower than those of liver cirrhosis ,liver failure and liver cancer group(P<0 .05) .And in the liver failure group ,PT(30 .03 ± 3 .12) s ,D-D(4828 .0 ± 798 .3)mg/L and FDP(12 .83 ± 2 .44)mg/mL were significant higher than those of the chronic hepatitis B ,liver cirrhosis ,liver failure group(P<0 .05) .The highest value of TT[(33 .15 ± 4 .59)s]was in liver failure and the lowest value was in chronic hepatitis B[(18 .98 ± 0 .50)s] .The differences between liver failure group and other groups were significant (P<0 .05) .The lowest and the highest value of AT-Ⅲ among all groups was in liver failure group[(28 .30 ± 2 .25)% ] and chronic hepatitis group [(70 .36 ± 2 .81)% ] respectively .The value of AT-Ⅲ in the liver cirrhosis group was(55 .90 ± 2 .79)% ,the difference between liver failure group and other groups were significant(P<0 .05) .The value of FIB in the liver cancer group was (3 .13 ± 0 .24)g/L ,which showed significant differences compared with the other three groups (P<0 .05) .Conclusion As the clinical classification of patients with hepatitis B is worse ,the function of blood coagulation will be worse too .关键词
乙型肝炎/凝血功能/临床分型Key words
hepatitis B/blood coagulation function/clinical classification引用本文复制引用
赵妮娜,杨玉婷,周芬,华彦珺,顾国林,陈慧,胥萍..慢性乙型肝炎患者病程转归与凝血功能相关指标分析[J].检验医学与临床,2017,14(3):314-316,3.基金项目
江苏省苏州市科学技术局资助项目(SYS201433、SZS201006) （SYS201433、SZS201006）
江苏省苏州市卫生局科技项目(LCZX201414). （LCZX201414）
