临床肝胆病杂志2017，Vol.33Issue(1)：72-75,4.DOI:10.3969/j.issn.1001-5256.2017.01.015
女性肝硬化患者性激素水平变化的初步探讨
A preliminary study of the changes in sex hormone levels in female patients with liver cirrhosis
摘要
Abstract
Objective To investigate the characteristics of the changes in sex hormone levels in female patients with liver cirrhosis.Meth-ods A total of 30 female patients with liver cirrhosis who visited or were hospitalized in Beijing Ditan Hospital,Capital Medical University from September 2014 to June 2015 were enrolled as liver cirrhosis group,and 30 non -cirrhotic female patients who had no chronic liver dis-ease and visited the hospital due to other diseases or underwent physical examination were enrolled as the control group.The serum levels of estradiol (E2 ),follicle -stimulating hormone (FSH),luteinizing hormone (LH),prolactin (PRL),progesterone (PRGE),and testoster-one (T)were measured in both groups,and the proportion of menopausal women and sex hormone levels were compared between the two groups.The chi -square test was used for comparison of categorical data between groups,and the t -test was used for comparison of contin-uous data between groups.Results There were 13 menopausal women (43.33%)in the control group and 23 (76.67% )in the liver cir-rhosis group,and the liver cirrhosis group had a significantly higher proportion of menopausal women than the control group (χ2 =6.944, P =0.008).Compared with the control group,the liver cirrhosis group had a significantly lower level of E2 (t =4.489,P <0.01)and sig-nificantly higher levels of FSH and T (t =-5.010 and -4.082,both P <0.01).Conclusion There are differences in the levels of some sex hormones between female patients with liver cirrhosis and healthy women,and female patients with liver cirrhosis have different charac-teristics of the changes in sex hormone levels from male counterparts,which may be related to the development and progression of chronic liv-er diseases.This suggests that sex hormone therapy for patients with liver cirrhosis needs further investigation.关键词
肝硬化/性腺甾类激素/女(雌)性Key words
liver cirrhosis/gonadal steroid hormones/female分类
医药卫生引用本文复制引用
李丽,李红芳,易为,庄虔莹,胡玉红,蒋红丽..女性肝硬化患者性激素水平变化的初步探讨[J].临床肝胆病杂志,2017,33(1):72-75,4.基金项目
首都医科大学附属北京地坛医院院内科研基金“启航计划”项目 （）
