临床肝胆病杂志2017，Vol.33Issue(1)：130-132,3.DOI:10.3969/j.issn.1001-5256.2017.01.028
神经前体细胞表达下调蛋白9在胰腺癌组织中的表达及临床意义
Expression of NEDD9 and its clinical significance in pancreatic cancer
摘要
Abstract
Objective To investigate the expression of neural precursor cell -expressed,developmentally down -regulated 9 (NEDD9)in pancreatic cancer tissues and adjacent tissues and its association with the progression and prognosis of pancreatic cancer.Methods A total of 98 patients with pancreatic cancer who were treated in The Third People′s Hospital of Wuxi from August 2005 to December 2010 were en-rolled,and the samples of pancreatic cancer tissues and adjacent tissues were collected.Immunohistochemistry was used to measure the ex-pression of NEDD9 in pancreatic cancer tissues and adjacent tissues.The chi -square test was used for comparison of categorical data be-tween groups.Results The high expression rate of NEDD9 in pancreatic cancer tissues was significantly higher than that in adjacent tissues (57.1% vs 41.8%,χ2 =4.592,P =0.032).The expression of NEDD9 in pancreatic cancer tissues was significantly associated with TNM stage,degree of tumor differentiation,and lymph node metastasis (χ2 =45.02,20.41,and 36.21,all P <0.001)and not associated with sex,age,tumor location,or presence or absence of liver metastasis (all P >0.05).Conclusion NEDD9 may play a role in the progres-sion and invasion /metastasis of pancreatic cancer and can be used as a prognostic marker and a therapeutic target for pancreatic cancer.关键词
胰腺肿瘤/神经前体细胞表达下调蛋白 9/病理状态,体征和症状Key words
pancreatic neoplasms/NEDD9/pathological conditions,signs and symptoms分类
医药卫生引用本文复制引用
吴铁龙,薛丽莉,戴圆圆,盛颖玥,王文远,薛育政..神经前体细胞表达下调蛋白9在胰腺癌组织中的表达及临床意义[J].临床肝胆病杂志,2017,33(1):130-132,3.基金项目
江苏省“六大人才高峰”基金（WSN －066）；江苏省“333工程”科研项目（CAE01101－06）；无锡市医院管理中心科研项目（YGZXQ1310）；无锡市社会发展科技支撑项目 （）
