摘要
Abstract
Objective To investigate the expression of cysteinyl leukotriene receptor -1 (CysLTR -1)in pancreatic cancer tissue and its as-sociation with clinical features and prognosis.Methods A total of 42 patients with pathologically confirmed pancreatic cancer who were ad-mitted to Central Hospital of Huludao from January to October,2015 were enrolled,and cancer and adjacent tissues were collected.Real -time PCR was used to measure the relative mRNA expression of CysLTR -1 in these tissues,and the patients were followed up for 1 year. The t -test was used for comparison of continuous data between groups;an analysis of variance was used for comparison between multiple groups,and the least significant difference t -test was used for comparison between any two groups.The multivariate logistic regression anal-ysis was used to determine influential factors for the prognosis of patients with pancreatic cancer.Results The cancer tissues had signifi-cantly higher relative mRNA expression of CysLTR -1 than adjacent tissues (0.037 1 ±0.020 5 vs 0.016 8 ±0.011 4,t =6.58,P <0.001).The relative mRNA expression of CysLTR -1 was associated with TNMstage (t =2.731,P =0.009),degree of tumor differentia-tion (F =10.537,P <0.001),and lymph node metastasis (t =3.408,P =0.002).During the 1 -year follow -up,17 patients died and 25 survived;the patients who died had significantly higher relative mRNA expression of CysLTR -1 than those who survived (0.045 6 ± 0.021 7 vs 0.031 3 ±0.019 8,t =2.21,P =0.03).The logistic regression analysis showed that TNMstage (OR =6.92,95%CI:1.30 -36.82,P =0.02),degree of tumor differentiation (OR =5.71,95%CI:1.44 -22.62,P =0.01),and lymph node metastasis (OR =9.62,95%CI:2.23 -41.46,P <0.001)were prognostic factors for pancreatic cancer.After adjustment for age,sex,TNMstage,degree of tumor differentiation,tumor location,and lymph node metastasis,the mRNA expression of CysLTR -1 was still a prognostic factor for patients with pancreatic cancer (OR =1.11,95%CI:1.07 -1.15,P =0.03).Conclusion CysLTR -1 is involved in the development and pro-gression of pancreatic cancer and can be used as a new molecular marker for prognostic evaluation in patients with pancreatic cancer.关键词
胰腺肿瘤/受体,白三烯/肿瘤标记,生物学Key words
pancreatic neoplasms/receptors,leukotriene/tumor markers,biological分类
医药卫生
