临床肝胆病杂志2017，Vol.33Issue(1)：146-149,4.DOI:10.3969/j.issn.1001-5256.2017.01.032
肝移植术后发生人细小病毒 B19相关纯红细胞再生障碍性贫血的临床特点分析
Clinical features of pure red cell aplasia associated with human parvovirus B19 infection after liver transplantation
摘要
Abstract
Objective To investigate the clinical features of patients with pure red cell aplasia (PRCA)associated with human parvovirus B19 (HPV B19)infection after liver transplantation.Methods The clinical data of 420 patients who underwent liver transplantation in 302 Hospital of PLA from July 2007 to July 2016 and were followed up regularly were collected,and among these patients,five had a progressive reduction in hemoglobin (Hb)level within a short period of time.Bone marrow cytological examination showed erythropoiesis disorders and positive HPV B19 IgM,and the patients were diagnosed with PRCA after the exclusion of other causes.The patients were given human gam-ma -globulin,glucocorticoids,and adjustment of immunosuppressants.The patients′clinical manifestations during treatment and the chan-ges in reticulocyte count (RC),Hb,white blood cell count (WBC),platelet count (PLT),and myelogram findings determined by periph-eral blood cell analysis were observed,as well as the changes in liver and renal function parameters.Results After the multimodality thera-py using human gamma -globulin,glucocorticoids,and red blood cell infusion,the five patients had significant alleviation in the symptoms of weakness,short breath,and dizziness,and the peripheral blood cell analysis showed recovery of Hb and RC,suggesting that anemia was corrected.Conclusion As for patients with PRCA associated with HPV B19 infection,early diagnosis and treatment with human gamma -globulin and glucocorticoids can achieve a good therapeutic effect.关键词
肝移植/细小病毒 B19,人/贫血Key words
liver transplantation/parvovirus B19,human/anemia分类
医药卫生引用本文复制引用
张达利,臧红,高银杰,郭桐生,周霞,贺希,刘鸿凌..肝移植术后发生人细小病毒 B19相关纯红细胞再生障碍性贫血的临床特点分析[J].临床肝胆病杂志,2017,33(1):146-149,4.基金项目
首都市民健康培育（Z161100000116058）；三○二医院基金项目 （）
