临床肝胆病杂志2017，Vol.33Issue(1)：175-179,5.DOI:10.3969/j.issn.1001-5256.2017.01.041
肿瘤坏死因子α诱导蛋白8样分子2在肝脏及胃肠道肿瘤发生发展中的作用
Role of tumor necrosis factor -alpha -induced protein 8 -like 2 in development and progression of liver and gastro-intestinal tumors
摘要
Abstract
Liver and gastrointestinal tumors greatly threaten human health and have poor therapeutic outcomes and prognosis.Tumor necrosis factor -alpha -induced protein 8 -like 2 (TIPE2)can negatively regulate innate immunity and adaptive immunity and maintain immune ho-meostasis.Recent studies have found that TIPE2 can affect various signaling pathways and thus exerts an inhibitory effect on the development and progression of tumors.This article briefly introduces the structure and function of TIPE2 and its regulatory effect on tumor -related sig-naling pathways such as Ras,Ral,and Rac and downstream molecules,as well as the role of TIPE2 in liver and gastrointestinal tumors,re-lated signaling pathways,and research advances.关键词
肝肿瘤/胃肿瘤/肠肿瘤/肿瘤坏死因子 α诱导蛋白 8 样分子 2/综述Key words
liver neoplasms/stomach neoplasms/intestinal neoplasms/tumor necrosis factor -alpha -induced protein 8 -like 2/review分类
医药卫生引用本文复制引用
孔丽,金萌,赵素贤..肿瘤坏死因子α诱导蛋白8样分子2在肝脏及胃肠道肿瘤发生发展中的作用[J].临床肝胆病杂志,2017,33(1):175-179,5.基金项目
河北省科技厅课题（2015043467）；河北省卫生厅课题 （）
