临床误诊误治2017，Vol.30Issue(1)：91-94,4.DOI:10.3969/j.issn.1002-3429.2017.01.030
左甲状腺素替代治疗对甲状腺功能减退症患者血管内皮功能的影响
Effect of Levothyroxine Replacement Therapy on Vascular Endothelial Function of Patients with Hypothyroidism
摘要
Abstract
Objective To investigate the effect of Levothyroxine on vascular endothelial function of patients with hy-pothyroidism( DWH). Methods A total of 80 patients with hypothyroidism during January 2014 and Augest 2015 all re-ceived Levothyroxine orally. Levels of blood total triiodothyronine( TT3 ),free triiodothyronine( FT3 ),total thyroxine( TT4 ), free thyroxine( FT4 ),thyroid stimulating hormone( TSH),plasma antithrombin Ⅲ( AT-Ⅲ)activity and C-reactive protein (CRP),fibrinogen(FIB)and homocysteic acid(HCY),total cholesterol(TC),high density lipoprotein cholesterol ( HDL-C),low density lipoprotein cholesterol( LDL-C ),triglyceride( TG ) and brachial artery flow-mediated dilatation ( FMD)indexes before and after 6 months of treatment were compared. Multiple linear regression analysis was performed to analyze effects of each index on FMD function. Results After 6 months of treatment,TT3 ,FT3 ,TT4 ,FT4 ,AT-Ⅲ activity, HDL-C and FMD index levels were significantly higher,while TSH,CRP,FIB,HCY,TC,LDL-C and TG levels were signif-icantly lower than those before treatment(P﹤0. 05 or P﹤0. 01). Multiple linear regression analysis showed that TT3,TT4, FT4 ,TSH,CRP,HCY,TC and LDL-C were risk factors of FMD,while HDL-C and AT-Ⅲ activity were protection factor of FMD. Conclusion Levothyroxine treatment can improve FMD of patients with hypothyroidism.关键词
甲状腺功能减退症/左旋甲状腺素/血管内皮功能Key words
Hypothyroidism/Levothyroxine/Vascular endothelial function分类
医药卫生引用本文复制引用
潘伟,刘观鑫,韦彩芬,覃方生,陈聿峰..左甲状腺素替代治疗对甲状腺功能减退症患者血管内皮功能的影响[J].临床误诊误治,2017,30(1):91-94,4.基金项目
广西壮族自治区卫生和计划生育委员会自筹经费科研课题 （）
