器官移植2017，Vol.8Issue(1)：40-43,4.DOI:10.3969/j.issn.1674-7445.2017.01.008
他克莫司与其它药物相互作用致肾移植受者高钾血症10例临床分析
Clinical analysis on hyperpotassemia induced by pharmacologic interaction between tacrolimus and other drugs in 10 renal ;transplant recipients
摘要
Abstract
Objective To investigate the therapeutic methods of hyperpotassemia induced by excessively high blood concentration of tacrolimus (FK506) caused by drug use after renal transplantation. Methods Clinical data of 10 patients diagnosed with hyperpotassemia induced by excessively high blood concentration of FK506 after administration of antifunga l medication following renal transplantation were collected and retrospectively analyzed. Results At 1-2 months after renal transplantation, 10 patients suffered from pulmonary infectiono r pneumonia complicated with pulmonary fungal infection . An appropriate dose of compound sulfamethoxazole, micafungin, cefoperazone sodium-sulbactam sodium and moxifloxacin was administered for antifungal infection. After potassium-lowering therapy, termination of antifungal medication and FK506 dose adjustment (replaced by cyclosporin for certain cases), the serum level of potassium was declined and maintained within normal range for 10 cases. The serum concentration of FK506 was within normal range. No sign of excessively high level of potassium was observed without any potassium-lowering intervention. Conclusions Postoperative administration of drugs is likely to cause excessively high level of FK506 and hyperpotasesmia. Potassium-lowering therapy, termination of drug use and adjustment of immunosuppressive agents should be adopted to avoid the incidence of adverse pharmacologic interaction.关键词
他克莫司/相互作用/高钾血症/术后,肾移植/临床研究Key words
Tacrolimus/Interaction/Hyperpotassemia/Postoperative, Renal transplantation/Clinical trial分类
医药卫生引用本文复制引用
邱春燕,隋雨荧,于立新,邓文锋,苗芸,刘如敏,叶桂荣..他克莫司与其它药物相互作用致肾移植受者高钾血症10例临床分析[J].器官移植,2017,8(1):40-43,4.基金项目
国家自然科学基金（81500573）；南方医科大学南方医院院长基金（2013B011）；南方医科大学南方医院院级教育课题 （）
