山东医药2017，Vol.57Issue(2)：22-24,3.DOI:10.3969/j.issn.1002-266X.2017.02.006
初发糖尿病患者血清鸢尾素水平变化及意义
Changes in levels of serum irisin in patients with new-onset diabetes mellitus
摘要
Abstract
Objective To investigate the changes in levels of serum irisin in patients with new-onset diabetes mellitus (DM)and its association with various metabolic parameters.Methods Fifty-eight patients with new-onset DM (DM group)and 64 people with normal glucose tolerance (NGT group)were selected.Serum irisin was detected by ELISA and its associations with metabolic parameters 〔body mass index (BMI),body fat mass,body fat percentage,fasting plasma glucose (FPG),2 h post-load plasma glucose (2 h PG),Hemoglobin A1c ,fasting insulin,homeostasis model assessment-βvalue,insulin resistance index,total cholesterol,triglyceride,high-density lipoprotein cholesterol (HDL-C),low-densi-ty lipoprotein cholesterol (LDL-C)and free fatty acids (FFA)]were analyzed by Spearman bivariate correlation.Logistic regression analysis was performed to assess the association between irisin level and DM.Results The serum irisin levels in the DMgroup and NGT group were 238.03 (198.97,279.43)and 286.48 (241.88,355.19)ng/mL,respectively (P <0.01).Serum irisin level was negatively correlated with FPG (r =-0.246,P <0.01),2 h PG (r =-0.184,P <0.05),FFA (r =-0.199,P <0.05)and was positively correlated with HDL-C (r =0.254,P <0.01).Serum irisin lev-el was negatively correlated with DM(OR =0.994,95%CI:0.990 -0.998,P =0.005).Conclusion Serum irisin level is significantly decreased in patients with new-onset DM,which is negatively correlated with DM.关键词
鸢尾素/糖尿病/血糖/游离脂肪酸/高密度脂蛋白胆固醇Key words
irisin/diabetes mellitus/blood glucose/free fatty acids/high-density lipoprotein cholesterol分类
医药卫生引用本文复制引用
杨梅丽,陈培红,金华,于雪梅..初发糖尿病患者血清鸢尾素水平变化及意义[J].山东医药,2017,57(2):22-24,3.基金项目
上海市科学技术委员会资助项目（134119b2500）。 （）
