生物产业技术Issue(1)：64-70,7.DOI:10.3969/j.issn.1674-0319.2017.01.010
微生物代谢工程的研究进展和展望
Progress and prospect in microbial metabolic engineering
摘要
Abstract
Metabolic engineering has been proven crucial for the construction of microbial cell factories. The main objective of metabolic engineering is to increase the titer, yield and productivity of target chemicals through genetic engineering. However, genetic manipulations usually result in lower productivity due to growth impairment. With the development of tools in synthetic biology, there has been increasing interest in the dynamic regulation of metabolic flux to overcome the issues. Some metabolic engineering strategies allow trade-offs between growth and production to be better managed and can help avoid build-up of undesired intermediates. This paper summarizes the recent progress in the metabolic engineering and also prospects the future trends in this field.关键词
代谢工程/动态调控/合成生物学/发酵Key words
metabolic engineering/metabolic control/synthetic biology/fermentation引用本文复制引用
顾洋,李江华,堵国成,陈坚,刘龙..微生物代谢工程的研究进展和展望[J].生物产业技术,2017,(1):64-70,7.基金项目
国家优秀青年基金（31622001），自然基金面上项目 （）
