生物技术通报2017，Vol.33Issue(1)：58-63,6.DOI:10.13560/j.cnki.biotech.bull.1985.2017.01.006
合成生物学开关在代谢工程中的应用
Application of Switch for Synthetic Biology in Metabolic Engineering
摘要
Abstract
Translational switches for synthetic biology are mainly used to regulate gene expression in the field of metabolic engineering research. Traditional metabolic engineering regulates the expression of specific genes by using knockout and overexpression. However,the knockout of genes usually leads to the decrease in growth,therefore,we need to close and activate the expression of specific gene at proper time,and translational switche for synthetic biology is the key tool to solve such issue. At present,light-controlled switch,temperature-induced switch,toggle switch,and riboswitch are commonly used in metabolic engineering,of which the toggle switch and riboswitch present a great advantage in the dynamic regulation of gene expression. In this paper,several kinds of translational switches for synthetic biology and their applications in metabolic engineering are reviewed.关键词
合成生物学/基因表达调控/代谢工程/合成生物学开关/动态调控Key words
synthetic biology/gene expression regulation/metabolic engineering/switch for synthesis biology/dynamic regulation引用本文复制引用
庞庆霄,梁泉峰,祁庆生..合成生物学开关在代谢工程中的应用[J].生物技术通报,2017,33(1):58-63,6.基金项目
国家“973”项目子课题（2012CB725202），山东省科技发展计划项目 （）
