生物技术通报2017，Vol.33Issue(1)：99-105,7.DOI:10.13560/j.cnki.biotech.bull.1985.2017.01.010
微生物合成腺苷蛋氨酸的研究进展
Research Progress on the Synthesis of S-adenosyl-L-methionine in Microorganism
赵伟军 1黄磊 1徐志南1
作者信息
- 1. 浙江大学生物化学工程学院，杭州 310027
- 折叠
摘要
Abstract
S-adenosyl-L-methionine(SAM)as an important metabolite exists in all cell types of living organisms,presents promising effects on liver diseases and depressive syndromes without any side effects,thus,it is greatly demanded in medical market. Recently,broad studies on biosynthesis of SAM have been conducted by scholars in the world. On the one hand,fermentation strategies based on traditionally producing SAM were further improved ;on the other hand,different rational breeding programs were developed,such as fine tuning host’s metabolic network or screening strains by synthetic gene circuit. In this paper,progress in the research of S-adenosyl-L-methionine production is summarized,and the significances and issues while efficiently producing SAM by microorganism are discussed,aiming at providing the guides for improving SAM productivity at an industrial scale.关键词
腺苷蛋氨酸/酵母/基因电路/发酵/代谢改造Key words
S-adenosyl-L-methionine/yeast/synthetic gene circuit/fermentation/metabolic engineering引用本文复制引用
赵伟军,黄磊,徐志南..微生物合成腺苷蛋氨酸的研究进展[J].生物技术通报,2017,33(1):99-105,7.
