实用肿瘤杂志2017，Vol.32Issue(1)：44-47,48,5.
静脉推注速度对18 F-FES在血管壁残留的影响分析
Influence of intravenous injection speed on residual 18 F-FES in blood vessel wall
摘要
Abstract
Objective To examine the impact of intravenous injection speed on 1 8 F-fluoroestradiol (1 8 F-FES)resid-ual in blood vessel wall during breast PET/CT scan.Methods Twenty milliliter of 1 8 F-FES was administered intravenous-ly with two different speeds [experimental group:1 min (n=20);control group:2 min (n=32)]in 52 breast cancer pa-tients undergoing 1 8 F-FES PET/CT scan.The influencing factors of 1 8 F-FES residual on the blood vessel wall were ana-lyzed.Results The cord-like shape of 1 8 F-FES residual on the blood vessel wall was detected in 24 cases.There was no statistical difference in adverse effect rates between the experimental group and the control group (χ2 =0.332,P>0.05). Nevertheless,the occurrence rate of radiopharmaceutical residual on the blood vessel wall was significantly lower in experi-mental group than that in control group (χ2 =22.1 48,P<0.01 ).Logistic regression analysis showed the speed of intrave-nous injection as an independent factor (P<0.01 ).Besides,age,diabetes mellitus,hyperlipemia and recent history of chemotherapy,radiotherapy or endocrine therapy had no impact on the occurrence rate of 1 8 F-FES residual on the blood ves-sel wall (P>0.05).Conclusion A speed of 20 mL/min of 18F-FES intravenous injection can decrease the occurrence rate of radiopharmaceutical residual on the blood vessel wall without increasing the incidence of any other adverse effect.关键词
乳腺肿瘤/放射性核素显像/受体,雌激素/雌二醇/诊断应用/氟脱氧葡萄糖F1 8/诊断应用/体层摄影术,X线计算机/药物残留物/血管内膜/注射,静脉内/方法Key words
breast neoplasms/radionuclide imaging/receptors,estrogen/estradiol/diagnostic use/fluorodeoxyglucose F1 8/diagnostic use/tomography,X-ray computed/drug residues/tunica intima/injections,intravenous/methods分类
医药卫生引用本文复制引用
薛静,章英剑,杨忠毅,徐俊彦,张勇平,孙艺斐,王新村,姚之丰,岳勤,乔莹..静脉推注速度对18 F-FES在血管壁残留的影响分析[J].实用肿瘤杂志,2017,32(1):44-47,48,5.基金项目
上海市自然科学基金（15ZR1407600）；上海分子影像探针工程技术研究中心项目 （）
