摘要
Abstract
Objective To analyze the clinical value of carbohydrate antigen 1 9-9 (CA1 9-9),CA242 and carcinoem-bryonic antigen (CEA)combined detection in the diagnosis and clinical staging of pancreatic cancer.Methods Ninety-five cases of pancreatic cancer patients were selected as the patient group,and 60 cases of healthy subjects were enrolled as the control group.The expression levels of serum CA1 9-9,CA242,and CEA were compared between the two groups.The sensitivity,specificity and accuracy of serum CA1 9-9,CA242 and CEA detection alone and combined detection in the diag-nosis of pancreatic cancer were analyzed.Besides,the serum levels of the above biomarkers were compared in pancreatic cancer patients of different clinical stages.The role of these antigens in the clinical staging of pancreatic cancer was further evaluated.Results The serum levels of CA1 9-9,CA242 and CEA in the patients were significantly higher than those in the control group (P<0.05).The sensitivity,specificity and accuracy of biomarkers combined detection in diagnosing pan-creatic cancer were 96.8%,66.7% and 85.2%,respectively,and both the sensitivity and accuracy were higher than those of a single test.As the pathological stages of pancreatic cancer patients increased,the serum levels of CA1 9-9,CA242 and CEA were all significantly increased (P<0.05 ).Moreover,at 6 months after treatment,the serum levels of CA1 9-9, CA242 and CEA were significantly decreased,compared with those before treatment (P<0.05).Furthermore,patients with tumors ≥5 cm in diameter,or tumors located in the pancreatic body or tail,showed significantly higher levels of serum CA1 9-9,CA242 and CEA,compared to those patients with tumors <5 cm in diameter or tumors in the pancreatic head or the entire pancreas (P<0.05).Conclusion The combined detection of serum CA1 9-9,CA242 and CEA has important clinical value in the early diagnosis and staging of pancreatic cancer.关键词
胰腺肿瘤/诊断/胰腺肿瘤/病理学/CA-1 9-9 抗原/血液/癌胚抗原/血液/抗原,肿瘤相关,碳水化合物/血液/肿瘤标记,生物学/肿瘤分期Key words
pancreatic neoplasms/diagnosis/pancreatic neoplasms/pathology/CA-1 9-9 antigen/blood/carcinoem-bryonic antigen/blood/antigens,tumor-associated,carbohydrate/blood/tumor markers,biological/neo-plasm staging分类
医药卫生
