西安交通大学学报（医学版）2017，Vol.38Issue(1)：1-6,6.DOI:10.7652/jdyxb201701001
高血压中枢发病机制的研究进展
Advances in research on the central mechanism of hypertension
摘要
Abstract
ABSTRACT:Hypertension,the first risk factor for stroke and coronary heart disease in the Chinese population, seriously endangers people’s health.At present,China has more than 270 million people with hypertension and an annual increase rate of 1 0 million people.Then how to improve prevention and treatment of hypertension has become an urgent need to solve major medical and social problems.In the past,research on hypertension mainly focused on the peripheral area,while recent research has shown that the central regulation plays an important role in the development of hypertension. Hypothalamic paraventricular nucleus (PVN ), which plays a key role in maintaining cardiovascular activity, can directly control the sympathetic preganglionic neurons and regulate peripheral sympathetic nerve activity,thus being closely related to the development of hypertension.Research in recent years shows that the comprehensive effects of proinflammatory cytokines (PIC ),reactive oxygen species (ROS),renin-angiotensin system (RAS),neurotransmitter (NT)and nuclear factorκB (NF-κB)are involved in the pathogenesis of hypertension.However,it is unclear how these neurohormones in PVN are activated,how they interact with each other and what role they play in the regulatory mechanism of hypertension.Therefore,the key focus of this research is to explore the impact of activated neurohormones in PVN on hypertension.This study will provide new content for the study on hypertension.关键词
高血压/下丘脑室旁核/炎性细胞因子/活性氧簇/肾素-血管紧张素系统/神经递质/核因子κB(NF-κB)Key words
hypertension/hypothalamic paraventricular nucleus/proinflammatory cytokine/reactive oxygen species/renin-angiotensin system/neurotransmitter/nuclear factorκB分类
医药卫生引用本文复制引用
康玉明,李宏宝,齐杰,于晓静..高血压中枢发病机制的研究进展[J].西安交通大学学报（医学版）,2017,38(1):1-6,6.基金项目
国家自然科学基金重大研究计划项目(No.91439120)和国家自然科学基金面上项目(No.81370356、81170248、81070199) Supported by the National Natural Science Foundation of China (No.91439120,81370356,81170248,and 81070199) （No.91439120）
