中国组织工程研究2017，Vol.21Issue(2)：165-170,6.DOI:10.3969/j.issn.2095-4344.2017.02.001
生长因子复合支架材料在即刻种植周围骨缺损中的作用
Growth factor composite scaffolds for bone defect repair via immediate implantation of bone defects
摘要
Abstract
BACKGROUND:Nerve growth factor has been shown to play an important role in bone healing, but little is reported on the effect of growth factor composite scaffolds via the immediate implantation in the repair of canine bone defects. OBJECTIVE:To analyze the effect of nerve growth factor composite scaffolds via the immediate implantation for the repair of canine bone defects. METHODS:Nerve growth factor composited strontium apatite scaffolds were prepared. Canine mandibular defect models were established and divided into three groups, fol owed by implanted with composite scaffold (experimental group), strontium apatite (positive control group), or nothing (blank control group). The three-dimensional CT reconstruction and hematoxylin-eosin staining of canine mandibular bone defects were observed. RESULTS AND CONCLUSION:In the blank control group, there were few new bones surrounding bone defect. Trabecular bones spread from the defect center to the surrounding tissues in the experimental and positive control groups. The bone density, volume, thickness, and implant-bone contact were significantly increased, while the trabecular separation was significantly decreased in the experimental group compared with the positive control and blank control groups (P<0.05), and al above indicators in the positive contro group were significantly higher than those in the blank control group (P<0.05). Hematoxylin-eosin staining showed that in the experimental group, there were a large number of new bones that contacted with the surrounding bones closely, and trabecular bones arranged regularly. In the positive control group, newborn osteoid, trabeculare, and a smal amount of debris were found. In the blank control group, few new bones were connected with the surrounding bones untightly and trabecular bone arranged irregularly. These results indicate that the nerve growth factor composite scaffold can promote the bone regeneration in the canine bone defects after immediate implantation.关键词
生物材料/口腔生物材料/神经生长因子/锶磷灰石/支架材料/犬/即刻种植/骨缺损/骨生成分类
医药卫生引用本文复制引用
杨玉鹏,杨圣俊,程凤峡,谷建琦,郑瑶,李娟,郝玮,吴永生..生长因子复合支架材料在即刻种植周围骨缺损中的作用[J].中国组织工程研究,2017,21(2):165-170,6.基金项目
2014年度河北省医学科学研究课题计划(ZL20140216)Funding:the Medical Science Research Project of Hebei Province in 2014, No. ZL20140216 （ZL20140216）
