中国组织工程研究2017，Vol.21Issue(2)：177-181,5.DOI:10.3969/j.issn.2095-4344.2017.02.003
中空羟基磷灰石复合重组人骨形态发生蛋白2微球体修复骨缺损
Hollow hydroxyapatite combined with human bone morphogenetic protein-2 microspheres for bone defect repair
摘要
Abstract
BACKGROUND:Hydroxyapatite (HA) is a good scaffold material, and recombinant human bone morphogenetic protein-2 (rhBMP-2) possesses a strong osteogenic ability, therefore, by which preparing a novel composite material wil be helpful for bone repair. OBJECTIVE:To explore the effects of the hol ow HA/rhBMP-2 microspheres on the osteogenesis and biomechanics of rabbit bone defects. METHODS:Forty-eight male healthy adult New Zealand white rabbits were randomly divided into three groups (n=16 per group), including composite, single and control groups. Radical defect models were prepared, and the hol ow HA/rhBMP-2 and hol ow HA scaffolds were implanted into the composite and single groups, respectively. The control group received no treatment. At the 1st day of 4, 8, 12, and 16 weeks after implantation, the level of serum alkaline phosphatase was detected, and the bone healing was assessed through X-ray, three-dimensional CT, radionuclide bone scan and biomechanics testing, respectively. RESULTS AND CONCLUSION:The level of serum alkaline phosphatase, X-ray scale scores, osteogetic effect, region of interest volume, three-dimensional CT and biomechanical strength in the composite group were superior to those in the single group. In the meanwhile, the bone healing was unsatisfactory in the control group. Our findings indicate that the hol ow HA/rhBMP-2 artificial bone exhibits a good osteogenic ability and mechanical strength, contributing to bone healing.关键词
生物材料/骨生物材料/羟基磷灰石/中空微球/重组人骨形态发生蛋白2/人工骨替代物/骨缺损分类
医药卫生引用本文复制引用
唐智明,熊龙,曾建华,廖新根,李经堂,姚爱华,华福洲..中空羟基磷灰石复合重组人骨形态发生蛋白2微球体修复骨缺损[J].中国组织工程研究,2017,21(2):177-181,5.基金项目
江西省科技支撑计划(2009bsb10902)Funding:the Science and Technology Plan of Jiangxi Province, No.2009bsb10902 （2009bsb10902）
