新医学2017，Vol.48Issue(1)：60-62,3.DOI:10.3969/j.issn.0253-9802.2017.01.014
曲妥珠单抗单药治疗乳腺癌致左心室功能不全一例
Left ventricular dysfunction induced by trastuzumab treatment of breast cancer:a case report
摘要
Abstract
Trastuzumab is a molecular targeted drug for Her2-positive breast cancer patients.In this paper,we reported one case of right breast cancer presenting with left ventricular dysfunction after single use of trastuzumab once every 3 weeks.After the second time of use of trastuzumab,she gradually developed breath-lessness which aggravated in a supine position,accompanied with cough,abdominal distension and bilateral lower extremity edema.During hospitalization in the Department of Cardiology,she was diagnosed with left ventricular dysfunction by echocardiography and PET/CT.Before the treatment of trastuzumab,the left ventric-ular ejection fraction (LVEF)of the patient was 0.66 which decreased to 0.29 after usage of trastuzumab.She reported no medical history of hypertension,diabetes mellitus and coronary heart disease.Hence,the inci-dence of left ventricular dysfunction was probably correlated with the use of trastuzumab.Left ventricular dys-function was recovered after trastuzumab withdrawal and 40-day symptomatic treatment.The diagnosis and treatment of this case hinted that standard use of medication should be implemented.Adverse events should be intimately monitored according to the manufacturers'instructions to avert the incidence of severe consequences.关键词
曲妥珠单抗/乳腺癌/左心室功能不全Key words
Trastuzumab/Breast cancer/Left ventricular dysfunction引用本文复制引用
刘婧,巩会平,盛林,王永梅,鹿庆华..曲妥珠单抗单药治疗乳腺癌致左心室功能不全一例[J].新医学,2017,48(1):60-62,3.基金项目
山东省自然科学基金 （）
